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In South Africa young women bear a disproportionate burden of HIV infection however, risk factors for HIV acquisition are not fully understood in this setting. In a cohort of 245 women, we used proportional hazard regression analysis to examine the association of demographic, clinical and behavioural characteristics with HIV acquisition. The overall HIV incidence rate (IR) was 7.20 per 100 women years (wy), 95 % confidence interval (CI) 4.50-9.80. Women 18-24 years had the highest HIV incidence (IR 13.20 per 100 wy, 95 % CI 6.59-23.62) and were almost three times more likely to acquire HIV compared to women 25 years and older [adjusted Hazard Ratio (aHR) 2.61, 95 % CI 1.05-6.47]. Similarly, women in relationships with multiple sex partners had more than twice the risk of acquiring HIV when compared to women who had no partner or who had a husband or stable partner (aHR 2.47, 95 % CI 0.98-6.26). HIV prevention programmes must address young women's vulnerability and sex partner reduction in this setting.
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http://dx.doi.org/10.1007/s10461-015-1002-5 | DOI Listing |
Drug Alcohol Depend
August 2025
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Objective: To estimate the association between medical and legal gender affirmation with problematic substance use among transfeminine adults.
Methods: Data from a longitudinal cohort (The LITE Study) were analyzed (n = 1186). Participants were enrolled between March 2018 and August 2020 and followed for 2 years.
Analyst
September 2025
Department of Bioengineering, University of Washington, Seattle, WA 98105, USA.
Curable sexually transmitted infections (STIs) caused by the bacteria (CT) and (NG) are widespread globally. These infections are particularly dangerous for female patients, causing pelvic inflammatory disease, infertility, and increased risk of HIV acquisition. Vaginal self-swab sampling can improve access to STI screening but is still subject to treatment delays due to centralized processing.
View Article and Find Full Text PDFFront Public Health
September 2025
School of Public Health, University of Rwanda, Kigali, Rwanda.
Background: Female sex workers (FSWs) in sub-Saharan Africa bear a disproportionate burden of HIV acquisition. While pre-exposure prophylaxis (PrEP) is increasingly accessible in the region, limited data exist on FSWs awareness of and willingness to use PrEP. This study aimed to assess PrEP awareness and willingness to use it, along with associated factors, among FSWs in Kigali, Rwanda.
View Article and Find Full Text PDFAIDS Behav
September 2025
Department of Epidemiology, Program for Implementation and Equity Research, Center for Public Health and Human Rights, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Information, education, and communication programs to improve HIV knowledge and communication skills are critical to HIV responses. It is unclear if improved HIV knowledge translates to decreased HIV acquisition risks. We identified typologies of HIV knowledge to assess the relationship with HIV risk perceptions and prevention behaviors using data from reproductive-aged adults without previously diagnosed HIV at screening for entry into the RV393 HIV incidence cohort in Kisumu County, Kenya.
View Article and Find Full Text PDFmedRxiv
August 2025
Infectious Diseases Institute, Makerere University, Kampala, Uganda.
Objective: Our study aimed to determine the prevalence and correlates of sexually transmitted infections (STIs) among adolescent girls and young women (AGYW) employed as household domestic workers in Kampala, Uganda.
Methods: Ugandan AGYW aged 14-24 participated in a community-based cross-sectional study in the Kampala Metropolitan Area from November 2023 to March 2024. Self-collected vaginal swabs were tested for (NG) and (CT) using GeneXpert.