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http://dx.doi.org/10.1097/PCC.0000000000000298 | DOI Listing |
Cardiol Rev
September 2025
Department of Medicine, New York Medical College, Valhalla, NY.
Atrial fibrillation (AF) is a prevalent and complex cardiac arrhythmia requiring multifaceted management strategies. This review explores the integration of large language models (LLMs) and machine learning into AF care, with a focus on clinical utility, privacy preservation, and ethical deployment. Federated and transfer learning methods have enabled high-performance predictive modeling across distributed datasets without compromising data security.
View Article and Find Full Text PDFExtracorporeal blood purification (EBP) is an emerging technique for reducing elevated levels of inflammatory mediators and/or endotoxins in critically ill patients with sepsis or other hyperinflammatory conditions. The oXiris filter combines endotoxin adsorption, cytokine adsorption, hemofiltration and anti-thrombosis, and an emerging body of evidence demonstrates its use in critical care patients with hyperinflammatory conditions and acute kidney injury (AKI). A group of Asia-Pacific experts convened to formulate consensus statements for the use of the oXiris filter based on a comprehensive review of publications.
View Article and Find Full Text PDFFront Physiol
August 2025
Department of Ultrasound, Deyang People's Hospital, Deyang, Sichuan, China.
Background: Antiphospholipid syndrome (APS) is a major immune-related disorder that leads to adverse pregnancy outcomes (APO), including recurrent miscarriage, placental abruption, preterm birth, and fetal growth restriction. Antiphospholipid antibodies (aPLs), particularly anticardiolipin antibodies (aCL), anti-β2-glycoprotein I antibodies (aβ2GP1), and lupus anticoagulant (LA), are considered key biomarkers for APS and are closely associated with adverse pregnancy outcomes. This is a prospective observational cohort study to use machine learning model to predict adverse pregnancy outcomes in APS patients using early pregnancy aPL levels and clinical features.
View Article and Find Full Text PDFExp Clin Transplant
August 2025
>From the Department of Urology, University Hospital Hradec Kralove, Hradec Kralove, Czechia; and the Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czechia.
Objectives: Kidney transplant is a life-saving procedure for patients with end-stage renal disease. Success of kidney transplant is highly dependent on maintaining the integrity of the endothelium and its protective layer, the endothelial glycocalyx. Ischemia-reperfusion injury, a common challenge in kidney transplant, can disrupt the endothelial glycocalyx, leading to various post-transplant complications.
View Article and Find Full Text PDFEur J Clin Pharmacol
September 2025
Department of Pharmacology and Toxicology, Faculty of Medical Sciences, University of Kragujevac, 34000, Kragujevac, Serbia.
Background: Heparin-induced thrombocytopenia (HIT) is a severe primary hypercoagulable disorder, particularly concerning in hemodialysis (HD) patients frequently exposed to heparin. Fondaparinux has emerged as a potential alternative anticoagulant, though supporting evidence is limited. This systematic review aimed to evaluate the safety and efficacy of fondaparinux in HD patients with HIT.
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