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http://dx.doi.org/10.2350/14-10-1559-LET.1 | DOI Listing |
Cytometry B Clin Cytom
September 2025
School of Medical Sciences, Universidade Estadual de Campinas (Unicamp), Campinas, Brazil.
Acute promyelocytic leukemia (APL) is a medical emergency that needs immediate diagnosis and treatment. Podoplanin, a transmembrane glycoprotein that binds CLEC-2 on platelets, was recently demonstrated to be abnormally expressed in leukemic blasts in APL, as opposed to other forms of AML, in a study using thawed primary cells. This study aimed to explore and validate the diagnostic accuracy of measuring podoplanin expression by flow cytometry in the differential diagnosis of APL and other forms of acute myeloid leukemia (AML) as part of the diagnostic work-up of all cases suspected of AML in an academic hematology center.
View Article and Find Full Text PDFACS Sens
September 2025
Institute of Applied Mechanics, National Taiwan University, Taipei 106, Taiwan.
In recent AI-driven disease diagnosis, the success of models has depended mainly on extensive data sets and advanced algorithms. However, creating traditional data sets for rare or emerging diseases presents significant challenges. To address this issue, this study introduces a direct-self-attention Wasserstein generative adversarial network (DSAWGAN) designed to improve diagnostic capabilities in infectious diseases with limited data availability.
View Article and Find Full Text PDFCNS Neurosci Ther
September 2025
College of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin, China.
Background: Neurological diseases such as stroke or Parkinson's disease are often accompanied by weakening or loss of proprioception, which seriously affects the motor control ability of the patients. However, proprioception rehabilitation is challenging due to the pain caused by impaired joints and the hard efforts that patients have to make during training. This study investigated the cross-transfer effect of short-term visuomotor training to the untrained wrist from the trained wrist, from both views of behavioral results and brain activity analyses.
View Article and Find Full Text PDFJ Med Internet Res
September 2025
Department of Precision Medicine, Faculty of Health, Medicine and Life Sciences, Maastricht University, Universiteitssingel 40, Maastricht, 6229 ER, The Netherlands, 31 433883549.
Background: Making informed decisions about clinical trial participation can be overwhelming for patients due to the complexity of trial information, potential risks and benefits, and the emotional burden of a recent diagnosis. Patient decision aids (PDAs) simplify this process by providing clear information on treatment options, empowering patients to actively participate in shared decision-making with their doctors. While PDAs have shown promise in various health care contexts, their use in clinical trials, particularly in the form of trial-specific patient decision aids (tPDAs), remains underused.
View Article and Find Full Text PDFInt J Paediatr Dent
September 2025
Lokman Hekim University, Faculty of Dentistry, Department of Pediatric Dentistry, Ankara, Turkey.
Background: Differentiating between primary and permanent teeth is a critical component of oral health knowledge, influencing both preventive care and clinical decisions. With the growing use of artificial intelligence (AI) in healthcare and education, its role in supporting learning is of increasing interest.
Aim: This study evaluated the diagnostic accuracy and internal consistency of ChatGPT-4.