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This paper studies the existence of solutions for a system of coupled hybrid fractional differential equations with Dirichlet boundary conditions. We make use of the standard tools of the fixed point theory to establish the main results. The existence and uniqueness result is elaborated with the aid of an example.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157214 | PMC |
http://dx.doi.org/10.1155/2014/426438 | DOI Listing |
BMC Womens Health
September 2025
Society for Family Health-Nigeria, Abuja, Nigeria.
Background: Interventions aimed to increase healthcare provider empathy and capacity to deliver person-centered care have been shown to improve healthcare seeking and outcomes. In the context of self-injectable contraception, empathetic counseling and coaching may be promising approaches for addressing "fear of the needle" among clients interested in using subcutaneous depot medroxyprogesterone (DMPA-SC). In Nigeria, the Delivering Innovation in Self-Care (DISC) project developed and evaluated an empathy-based in-service training and supportive supervision intervention for public sector family (FP) planning providers implemented in conjunction with community-based mobilization.
View Article and Find Full Text PDFAnn Biomed Eng
September 2025
Department of Mechanical Engineering, Koc University, Rumeli Feneri Campus, Sarıyer, 34450, Istanbul, Turkey.
Purpose: The design and development of ventricular assist devices have heavily relied on computational tools, particularly computational fluid dynamics (CFD), since the early 2000s. However, traditional CFD-based optimization requires costly trial-and-error approaches involving multiple design cycles. This study aims to propose a more efficient VAD design and optimization framework that overcomes these limitations.
View Article and Find Full Text PDFHandb Exp Pharmacol
September 2025
Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Research conducted over the last 15 years indicates that cAMP is generated not just from the plasma membrane but also from intracellular compartments, particularly in endosomes, where receptors are redistributed during the endocytosis process. This review centers on the parathyroid hormone type 1 receptor (PTHR) as a model for a peptide hormone GPCRs that generates cAMP from various locations with distinct duration and pharmacological effectiveness. We discuss how structural dynamics simulations aid in designing ligands that induce cAMP location bias, ultimately answering how the spatiotemporal generation of cAMP affects pharmacological responses mediated by the PTHR.
View Article and Find Full Text PDFHandb Exp Pharmacol
September 2025
Tsinghua University, Beijing, China.
The μ-opioid receptor (μOR) is the primary drug target of opioid analgesics such as morphine and fentanyl. Activation of μORs in the central nervous system inhibits ascending pain signaling to the cortex, thereby producing analgesic effects. However, the clinical use of opioid analgesics is severely limited by adverse side effects, including respiratory depression, constipation, addiction, and the development of tolerance.
View Article and Find Full Text PDFISA Trans
August 2025
Department of Vehicle Engineering and Jiangsu Engineering Research Center of Vehicle Distributed Drive and Intelligent Wire Control Technology, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China; Department of Vehicle Engineering and Jiangsu Engineering Research Center of Vehi
The steer-by-wire (SbW) system, as the core component of vehicle steering, needs to track the front wheel angle accurately. To mitigate the angle tracking accuracy degradation caused by D-Q axes coupling, time-varying motor electrical parameters, and load disturbance, a fractional-order adaptive fuzzy decentralized tracking control (FAFDTC) strategy is proposed in this paper. First, considering time-varying motor parameters, D-Q axes coupling, and fractional-order characteristics of components, a fractional-order SbW interconnected system is constructed to enhance its ability to characterize nonlinearities, time-varying dynamics, and system coupling.
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