Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Several variants within gene-encoding endothelial isoform of nitric oxide synthase have been reported to confer prostate cancer (PCa) susceptibility and/or progression. Nevertheless, studies referring to this issue have yielded inconsistent results. In order to elucidate the involvement of these variants in prostate carcinogenesis, we have conducted a meta-analysis of previously published case-control and relevant case-only studies. Eleven studies comprising in total 3,806 cases and 4,466 controls were included in the meta-analysis which yielded evidence of association of rs2070744 (ORCC = 1.43, 95% CI 1.04-1.97; p = 0.03) and intron 4a/b variant (ORab+aa = 1.47, 95% CI 1.00-2.14; p = 0.05) with PCa risk under recessive and dominant model, respectively. Furthermore, PCa patients carrying 4a/b a allele were found to have an increased risk of cancer progression to a less differentiated form, characterized by a high Gleason score (OR = 2.29, 95% CI 1.51-3.49; p < 0.01) and to higher TNM stage (OR = 2.55, 95% CI 1.71-3.81; p < 0.01). These results support the involvement of NOS3 variants in molecular pathogenesis of PCa.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350916 | PMC |
| http://dx.doi.org/10.1111/cts.12203 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Endoplasmic reticulum stress regulates intestinal motility in acute pancreatitis by regulating the expression and phosphorylation of nNOS through IRE1α/XBP1s-PI3K/Akt signaling axis.
Cell Signal
September 2025
Department of Gastroenterology, The Second Affiliated Hospital of Guilin Medical University, Guilin 541199, China; Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, The Second Affiliated Hospital of Guilin Medical University, Guilin 541199, China; Guangxi Key Labora
Intestinal dysmotility is a major complication that significantly impacts the prognosis of acute pancreatitis (AP). The neuronal nitric oxide synthase (nNOS) -expressing neurons within the enteric nervous system promote intestinal relaxation via the release of nitric oxide (NO). As the rate-limiting enzyme of NO synthesis, nNOS directly regulates NO production, thereby modulating intestinal motility.
View Article and Find Full Text PDFSex differences in childhood atopic disease and the role of sex-steroid metabolites.
J Allergy Clin Immunol Pract
September 2025
COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Background: Studies have described sex differences in childhood asthma, allergy, and atopic dermatitis, but the development and clinical phenotype of these differences remain poorly understood.
Objective: To characterize sex differences in atopic disease throughout childhood and study the potential role of sex-steroid metabolites.
Methods: We examined sex differences in asthma, allergy, and atopic dermatitis using longitudinal generalized estimating equation models in the COPSAC (n=411) and COPSAC (n=700) birth cohorts.
The harvesting technique affects the production of nitric oxide and endothelin in the internal thoracic artery graft.
J Thorac Cardiovasc Surg
September 2025
Department of Cardiovascular Surgery, Kanazawa University, Takaramachi 13-1 Kanazawa 920-8641, Japan.
Objective: To assess the production of nitric oxide and endothelin in off-pump coronary artery bypass grafting by comparing two techniques of internal thoracic artery preparation: skeletonized and pedicled without endothoracic fascia.
Methods: In this prospective, randomized clinical study, 40 patients undergoing off-pump coronary artery bypass grafting were randomized according to internal thoracic artery preparation technique into the skeletonized or pedicled (without endothoracic fascia) groups (n=20 each). Endothelial expression of CD31 was evaluated by means of immunohistochemistry and en-face immunofluorescence.
Metabolomics reveals glycerophospholipid metabolism as the action mechanism of Jin-Tian-Ge capsules in ameliorating inflammatory pain.
J Ethnopharmacol
September 2025
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China. Electronic address:
Ethnopharmacological Relevance: Chronic inflammatory pain represents a significant global health burden, seriously affecting the patient's quality of life. Jin-Tian-Ge Capsules (JTG), a substitute for natural tiger bone, has been approved in China for the treatment of osteoporosis, osteoarthritis and rheumatoid arthritis. Clinical observations show that JTG can mitigate chronic pain associated with the above bone-related diseases.
View Article and Find Full Text PDFNitric oxide regulates phagocytosis through S-nitrosylation of Rab5.
J Biol Chem
September 2025
Department of Oral Disease Research, National Center for Geriatrics and Gerontology, 7-430 Moriokacho, Obu, Aichi, 474-8511, Japan; Department of dental hygiene, Ogaki women's college, 109-1 Nishinokawa-cho, Ogaki-city, Gifu, 503-8554, Japan. Electronic address:
Phagocytosis is mediated mainly by immune cells, such as macrophages, monocytes and neutrophils, that clear large pathogens including bacteria. The small GTP-binding protein Rab5 is crucial for both clathrin-dependent endocytosis and phagocytosis, but the role and mechanism of Rab5 activation during phagocytosis are poorly understood. Here we report that nitric oxide (NO), a novel regulator of Rab5, regulates phagocytosis through S-nitrosylation of Rab5.
View Article and Find Full Text PDF