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http://dx.doi.org/10.3389/fnhum.2014.00442 | DOI Listing |
ArXiv
August 2025
Department of Genetics, Yale University, New Haven, CT 06510, USA.
A key output of the NIH-Common Fund 4D Nucleome (4DN) project is the open publication of datasets related to the structure of the human cell nucleus and the genome. Recent years have seen a rapid expansion of multiplexed Fluorescence In Situ Hybridization (FISH) or FISH-omics methods, which quantify the spatial organization of chromatin in single cells, sometimes together with RNA and protein measurements, and provide an expanded understanding of how 3D higher-order chromosome structure relates to transcriptional activity and cell development in both health and disease. Despite this progress, results from Chromatin Tracing FISH-omics experiments are difficult to share, reuse, and subject to third-party downstream analysis due to the lack of standard specifications for data exchange.
View Article and Find Full Text PDFFront Toxicol
August 2025
Reemtsma Cigarettenfabriken GmbH, An Imperial Brands PLC company, Hamburg, Germany.
Data from pre-clinical and clinical studies form part of an integrated assessment of the tobacco harm reduction (THR) potential of novel products that may act as cigarette alternatives for adult smokers. We report data from pre-clinical (emissions chemistry and toxicology) and clinical (nicotine pharmacokinetics and subjective effects) studies conducted with the iSENZIA™ heated herbal system (HHS; PULZE™ 2.0 device with iSENZIA™ sticks), which utilizes electronic heating of a tea-based substrate to generate an inhalable nicotine-containing aerosol.
View Article and Find Full Text PDFCurr Biol
August 2025
School of Science, Technische Universität Dresden, 01062 Dresden, Germany; Cluster of Excellence Physics of Life, Technische Universität Dresden, 01062 Dresden, Germany. Electronic address:
Many organs form globular structures, but how this is achieved is poorly understood. New work identifies an important role for an extracellular matrix and cellular projections in attaining the globular shape of halteres, flight balancing organs of dipteran insects.
View Article and Find Full Text PDFSci Rep
July 2025
Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, St. Paul, MN, 55108, USA.
Enzymes with industrial potential often face limitations due to stability and longevity constraints. Thermostable quorum quenching lactonases are appealing biotechnology tools for controlling microbial pathogenicity and biofilm formation via the interference of quorum sensing. However, the effective formulation of these enzymes remains a challenge.
View Article and Find Full Text PDFJ Pers Soc Psychol
June 2025
Department of Behavioral Science, University of Chicago Booth School of Business.
At times, goals seem to conflict, pulling people in opposite directions; at other times, they appear to complement or even facilitate one another, creating harmony. We propose and test a theoretical framework for understanding the antecedents and consequences of perceived goal harmony. We find that goal harmony can be enhanced through the cognitive process of mental integration, which includes identifying connections between goals (e.
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