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Haploidentical vs. Matched Sibling Donor HCT in Racially Diverse Pediatric and AYA Patients with Hematologic Malignancies: A Single-Center Comparison.
Transplant Cell Ther
September 2025
Department of Pediatrics, University of Arizona, Tucson, AZ, USA; Banner University Medical Center, Tucson, AZ, USA; BIO5 Institute, University of Arizona, Tucson, AZ, USA; The University of Arizona Cancer Center, Tucson, AZ, USA; Department of Immunobiology, University of Arizona, Tucson, AZ, USA;
Background: Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative treatment for pediatric patients with hematologic malignancies. Human leukocyte antigen (HLA)-matched sibling donors (MSDs) are considered the optimal source for stem cell transplantation; however, up to 70% of patients lack an MSD. This disparity is particularly pronounced among racial and ethnic minorities, who face challenges in identifying matched unrelated donors (MUDs).
View Article and Find Full Text PDFBackground: Functional immune reconstitution (IR) is a key factor in determining the success of hematopoietic stem cell transplantation (HSCT). IR depends on a number of factors and is typically delayed by ex vivo T cell depletion of the graft. αβ T cell depletion (αβ TCD) platform was reported to be associated with improved IR.
View Article and Find Full Text PDFFecal microbiota transplantation for Crohn's disease-like intestinal lesions arising after allogeneic stem cell transplantation.
Int J Hematol
August 2025
Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Several cases of inflammatory bowel disease (or similar gastrointestinal lesions) arising after allogeneic hematopoietic stem cell transplantation have been reported, but the effect of intestinal dysbiosis on development of these lesions remains unclear. We performed fecal microbiota transplantation (FMT) and 16S rRNA microbiome analysis in a patient who developed Crohn's disease-like lesions after allogeneic transplantation. A 62-year-old woman underwent haploidentical stem cell transplantation from her daughter to treat double-hit lymphoma relapsed after chimeric antigen receptor T-cell therapy, and achieved remission without developing acute graft-versus-host disease.
View Article and Find Full Text PDFLong-term efficacy of EBV-specific T cells for EBV-PTLD after allogeneic stem cell transplantation: a real word study.
Transplant Cell Ther
August 2025
Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Peking University, Beijing, China;. Electronic address:
Background: Epstein-Barr virus-associated post-transplant lymphoproliferative disorder (EBV-PTLD) remains a life-threatening complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT), especially in rituximab-refractory cases. Adoptive transfer of EBV-specific cytotoxic T lymphocytes (EBV-CTLs) offers a promising strategy to restore antiviral immunity, but long-term efficacy data, particularly in haploidentical transplant recipients, remain limited.
Methods: We conducted a retrospective study of 41 haploidentical HSCT recipients diagnosed with EBV-PTLD and received donor-derived EBV-CTLs.
Risk factors for invasive fungal infections in adult patients with hematological malignancies and/or stem cell transplant: a systematic review and meta-analysis.
Sci Rep
August 2025
Sorbonne Université, INSERM, Institut Pierre Louis d'Épidémiologie et de Santé Publique, Paris, F75012, France.
Unlabelled: Improving prevention and treatment strategies for invasive fungal infections (IFI) is essential to reduce associated morbidity and mortality. We performed a systematic review and meta-analyses to assess factors associated with IFI in adult patients with hematological malignancies and/or hematopoietic stem cell transplantation (HSCT).
Data Sources: We searched PubMed, Embase, CENTRAL and the grey literature from 01/01/2002 to 08/02/2024.