Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
A 77-year-old patient treated with ipilimumab (anti-CTLA-4 antibody) for metastatic melanoma developed autoimmune pancytopenia (anemia, thrombocytopenia, and neutropenia) 8 days after the fourth infusion. This pancytopenia was resistant to high-dose oral corticosteroids (1 mg/kg) and to hematopoietic growth factors. It resolved after intravenous immunoglobulins injection. To date, only 1 case of autoimmune pancytopenia has been reported after this treatment. According to the case that we report, it seems essential to control the leukocyte count before any injection of ipilimumab.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/CJI.0000000000000041 | DOI Listing |
Publication Analysis
Top Keywords
autoimmune pancytopenia
12
metastatic melanoma
8
ipilimumab-induced autoimmune
4
pancytopenia
4
pancytopenia case
4
case metastatic
4
melanoma 77-year-old
4
77-year-old patient
4
patient treated
4
treated ipilimumab
4