98%
921
2 minutes
20
Abstract: Suxamethonium chloride is a depolarizing muscle relaxant used in general anesthesia. In overdose, it causes adverse reactions such as bradycardia, arrhythmia, cardiac arrest, and death. The article reviews the progress on testing methods of suxamethonium chloride such as infrared spectroscopy, chemical color reaction, chemical titration, enzyme electrode, chromatography and mass spectrometry.
Download full-text PDF |
Source |
---|
Cureus
July 2025
Anesthesiology and Perioperative Medicine, University of Miami, Miami, USA.
In a nonendemic setting, the confluence of malaria and pregnancy presents unique anesthetic challenges, particularly when the infection is undiagnosed at the time of an urgent cesarean section. This report involves a woman in her early 30s at 39 weeks of gestation with no prior health issues, who developed malarial symptoms upon returning from Haiti five months before. During labor, severe fetal heart rate decelerations necessitated immediate surgical intervention.
View Article and Find Full Text PDFBackground: Nonmotor symptoms are a critical focus in the management of Parkinson's disease (PD). Apathy is defined as a quantitative reduction in goal-directed activity, characterized by diminished initiative, interest, and emotional expression or responsiveness. It affects approximately 40% of patients with PD, severely impairing daily functioning and quality of life.
View Article and Find Full Text PDFAir Med J
August 2025
Boston MedFlight, Bedford, MA. Electronic address:
Rapid sequence intubation is a standard procedure in critical care transport (CCT). Owing to its numerous benefits and clinical uses, rocuronium has become the first-line neuromuscular blocking agent in rapid sequence intubation, supplanting succinylcholine in many transport services. The deferred resumption of muscle activity with rocuronium may delay administering analgesia or sedation after intubation, resulting in awareness while paralyzed.
View Article and Find Full Text PDFJ Perianesth Nurs
August 2025
Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center, Dallas, TX; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX; Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, TX.
Purpose: Quantitative pupillometry (QP) standardizes pupillary assessment and may assist in the assessment of patients undergoing general anesthesia with neuromuscular blockade. This study aimed to explore the effect of general anesthesia with neuromuscular blockade on QP values.
Design: A prospective observational study.
Pharmacotherapy
August 2025
Department of Pharmacy Practice, Massachusetts College of Pharmacy and Health Sciences, Boston, Massachusetts, USA.
Succinylcholine, a commonly used neuromuscular blocker, is hydrolyzed by the pseudocholinesterase (also known as butyrylcholinesterase) enzyme in the plasma to inactive metabolites. Individuals who have inherited genetic variants in the BCHE gene that result in decreased or no pseudocholinesterase enzyme activity are at increased risk of prolonged neuromuscular blockade with succinylcholine. Although succinylcholine/BCHE is one of the earliest identified pharmacogenomic drug/gene associations, clinical implementation remains the exception rather than the norm today.
View Article and Find Full Text PDF