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Aim: To review the utility of perfusion index (PI) in the evaluation of neonatal clinical conditions. Twenty-five manuscripts were reviewed. PI provides information about haemodynamic stability, illness severity, early neonatal respiratory outcome, low superior vena cava flow and subclinical chorioamnionitis.
Conclusion: PI is a valuable tool to assess the newborn's health condition and could become a standardised measure in clinical evaluation. Different study designs are necessary to provide further validation to this method.
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http://dx.doi.org/10.1111/apa.12574 | DOI Listing |
Sci Rep
August 2025
Department of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
There is a lack of neuroimaging data and effective biomarkers in infants with mild hypoxic ischaemic encephalopathy (HIE). Cerebral reperfusion injury has shown potential as marker of neurodevelopmental outcome in moderate and severe HIE. We examined cerebral perfusion by using arterial spin labelling (ASL) in infants with mild HIE and its associations with adverse outcomes.
View Article and Find Full Text PDFClin Perinatol
September 2025
Department of Metabolism and Systems Science, College of Medical Sciences, University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK.
Pulse oximetry screening (POS) is a noninvasive tool for the detection of critical congenital heart defects (CCHD) that has moderate sensitivity and high specificity. It is readily accepted by parents and health care professional and has significantly reduced mortality from CCHD. This article discusses the impact of POS on CCHD screening, variations in algorithms used for implementation, practical aspects of POS programs, and challenges such as the effects of skin color and low detection rates for left-sided obstructive lesions, along with recent efforts to address these limitations by incorporating perfusion index and machine learning into POS algorithms.
View Article and Find Full Text PDFPediatr Nephrol
August 2025
Neonatal Intensive Care Unit and Neonatology, Fondazione IRCCS San Gerardo dei Tintori, Via Pergolesi 33, 20900, Monza, Italy.
Background: To evaluate the incidence and potential predisposing factors for the development of acute kidney injury (AKI) in asphyxiated neonates undergoing hypothermic treatment.
Methods: This retrospective study was conducted at the Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy. All neonates above 34 weeks of gestation diagnosed with hypoxic-ischemic encephalopathy (HIE) and treated with hypothermia, weighing more than 1800 g, admitted from January 1, 2013 to December 31, 2022, were included.
Sci Rep
August 2025
Department of Neonatology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Cerebral blood flow (CBF) is crucial for supplying the brain with the oxygen and nutrients necessary for its proper development and metabolism. The poor autoregulation of CBF is believed to play a role in the development of brain injury in preterm infants. This study aimed to investigate the characteristics of CBF in perinatal brain injury.
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August 2025
Department of Mathematics, Colorado State University, Fort Collins, 80523, CO, USA.
Electrical impedance tomography (EIT) is a bedside imaging technique in which voltage data arising from current applied on electrodes is used to compute images of admittivity in real time. Due to the severe ill-posedness of the inverse problem, good spatial resolution poses a challenge in EIT. Conversely, the temporal resolution is high, facilitating dynamic bedside imaging.
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