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Endogenous endophthalmitis is a rare ocular infection affecting the vitreous and/or aqueous humours. It is associated with poor visual prognosis and its commonest endogenous aetiology is infective endocarditis. The causative organisms of endogenous endophthalmitis complicating endocarditis are mainly Group A or B streptococci. The identification of Group C and G streptococci such as Streptococcus dysgalactiae is comparatively uncommon and has only been reported in a few case reports or series. We therefore report a case of infective endocarditis caused by Streptococcus dysgalactiae first presenting with endogenous endophthalmitis, the most likely source being osteomyelitis of both feet in a patient with type I diabetes. The patient was treated with a course of intravenous benzylpenicillin, intravitreal antibiotics, bilateral below knee amputations and mitral valve replacement. She survived all surgical procedures and regained partial visual acuity in the affected eye.
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http://dx.doi.org/10.4081/idr.2012.e16 | DOI Listing |
Front Vet Sci
August 2025
Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche "Togo Rosati", Perugia, Italy.
, a multi-host pathogen commonly isolated from dogs and cats has been occasionally reported in severe cases of human infection. This study aimed to explore the genetic diversity, antimicrobial resistance (AMR), and pathogenicity of isolates collected between 2004-2021, in Italy. Fifty-five isolates from clinical cases in domestic animals were investigated for susceptibility to antibiotics and then characterized for sequence type (ST), virulence profile, and antimicrobial-resistant genes through whole genome sequencing (WGS).
View Article and Find Full Text PDFAppl Environ Microbiol
August 2025
National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Khlong Luang, Pathum Thani, Thailand.
Bacteriophage endolysins are attractive alternatives to antibiotics owing to their rapid action, host specificity, and unlikeliness of resistance development. Here, bioinformatic analysis of prophage sequences identified an endolysin, named PlyCYU, containing two putative catalytic domains-an N-terminal amidase_5 and a C-terminal glucosaminidase (Lyz2) domain-with two CW_7 family cell wall binding motifs. PlyCYU exhibited bactericidal activity against , , and with a minimum bactericidal concentration (MBC) range of 1.
View Article and Find Full Text PDFInfect Immun
July 2025
Institute of Microbiology and Epizootics, School of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.
is an important opportunistic pathogen of cats, dogs, and cows, which can cause a range of infections, ranging from skin and soft tissue infections to septicemia and endocarditis. As a zoonotic agent, has also recently been implicated in serious human infections, following trauma or immunosuppression. In this work, we describe a novel protease of , termed IdeC (mmunoglobulin G egrading nzyme of ), which may be involved in bacterial immune evasion.
View Article and Find Full Text PDFBMC Vet Res
July 2025
Microbiology Area, Faculty of Medicine, University of Valladolid,, Avda. Ramón y Cajal, 7, Valladolid, 47005, Spain.
Background: Streptococcus dysgalactiae is the main cause of neonatal polyarthritis in sheep and is also an important agent in ovine mastitis. However, the main sources of contamination by this pathogen have not been studied in depth.
Case Presentation: A polyarthritis outbreak in 2-3-day-old lambs with an incidence rate of approximately 40%, was reported in a sheep farm focused on sheep's milk and lamb's meat.
mBio
August 2025
Laboratory for Molecular and Translational Human Infectious Diseases Research, Center for Infectious Diseases, Houston Methodist Research Institute, Houston, Texas, USA.
subspecies (SDSE) is a gram-positive bacterial pathogen capable of causing various infections in humans. Recently, isolates of SDSE type have emerged as a cause of severe invasive infections, including necrotizing myositis. However, the molecular processes underlying these infections remain poorly understood.
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