Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The number of drug-related emergency room visits in the United States doubled from 2004 to 2009 to 4.6 million. Consequently there is a critical need to rapidly identify the offending drug(s), so that the appropriate medical care can be administered. In an effort to meet this need we have been investigating the ability of surface-enhanced Raman spectroscopy (SERS) to detect and identify numerous drugs in saliva at ng/mL concentrations within 10 minutes. Identification is provided by matching measured spectra to a SERS library comprised of over 150 different drugs, each of which possess a unique spectrum. Trace detection is provided by fused gold colloids trapped within a porous glass matrix that generate SERS. Speed is provided by a syringe-driven sample system that uses a solid-phase extraction capillary combined with a SERS-active capillary in series. Spectral collection is provided by a portable Raman analyzer. Here we describe successful measurement of representative illicit, prescribed, and over-the-counter drugs by SERS, and 50 ng/mL cocaine in saliva as part of a focused study.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857074 | PMC |
| http://dx.doi.org/10.3390/pharmaceutics3030425 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Polyester-coated stainless-steel sheets using silica gel microparticles as surface pre-modifiers: a novel approach to determine selective serotonin reuptake inhibitors in saliva samples by direct infusion tandem mass spectrometry.
Mikrochim Acta
September 2025
Affordable and Sustainable Sample Preparation (AS2P) Research Group, Departamento de Química Analítica, Instituto Químico para la Energía y el Medioambiente IQUEMA, Universidad de Córdoba, Campus Universitario de Rabanales, Edificio Marie Curie, E-14071, Córdoba, Spain.
Stainless-steel substrates have grown in importance in the development of planar sorptive phases. However, the reduced wettability of polished sheets makes difficult their functionalization. This limitation can be solved by using amorphous silica gel microparticles as superficial guides.
View Article and Find Full Text PDFDesign, Development and Evaluation of Orally Disintegrating Mini-tablets (ODMTs) Containing Cefixime for Paediatric Use: A Novel Approach.
Turk J Pharm Sci
September 2025
Drugs Testing Laboratory, Department of Drugs Control, Bangalore, India.
Objectives: The study aimed to combine instant-release and mini-tablet methodologies to develop novel orally disintegrating mini-tablets (ODMTs) for a frequently pescribed antibiotic, cefixime trihydrate (CT), in paediatric patients.
Materials And Methods: CT-loaded microcapsules were prepared using Eudragit EPO and Hydroxy Propyl Methyl Cellulose E50 by spray drying technique. The optimized microcapsules were mixed with co-processed ready-to-use tableting excipients, Ludiflash and Pearlitol 200SD, in different proportions and then compressed into ODMTs and evaluated.
Advances in chitosan-based materials for oral ulcer treatment.
Carbohydr Polym
November 2025
Department of Pathology, the Affiliated Hospital of Qingdao University, Qingdao 266000, China. Electronic address:
Oral ulcers are a prevalent condition globally, causing significant pain and discomfort. The unique environment of the oral cavity, characterized by its humidity and dynamic nature, in conjunction with a diverse microbiome, presents challenges for traditional treatments for oral ulcers. Chitosan has emerged as a promising therapeutic agent for this condition.
View Article and Find Full Text PDFSaline nasal irrigation and gargling in COVID-19: Part II. Outcomes in Omicron and risk-benefit for self-care.
Front Public Health
September 2025
Department of Family and Community Medicine, Penn State University College of Medicine, Hershey, PA, United States.
Background: The World Health Organization recommends at-home management of mild COVID-19. While our preliminary evaluation provided evidence for saline nasal irrigation (SNI) and gargling in COVID-19, an update and risk-benefit assessment for self-care in Omicron infection is warranted, from treatment and preparedness perspectives, as new SARS-CoV-2 variants continuously emerge, while symptoms overlap with those of common colds and other upper respiratory tract infections.
Methods: Systematic literature searches for preclinical and clinical studies involving Omicron infection and saline, bias assessment, and review of outcomes (benefits, risks).
The impact of methylphenidate on oral health parameters, salivary flow rate, and quality of life in children with attention-deficit/hyperactivity disorder: a cross-sectional study.
Clin Oral Investig
September 2025
Department of Pediatric Dentistry, School of Dentistry, Marmara University, Istanbul, Türkiye.
Objectives: This study aimed to evaluate and compare the effects of methylphenidate on oral health, salivary flow rate, and quality of life in children with Attention-Deficit/Hyperactivity Disorder (ADHD), focusing on differences between short-release methylphenidate (SRM) and long-release methylphenidate (LRM) formulations.
Materials And Methods: A total of 99 children participated in this cross-sectional study (ADHD: n = 49; divided into SRM (n = 27) and LRM (n = 22) subgroups based on medication type; control: n = 50). Dental caries was assessed using the DMFT/dft indices and the International Caries Detection and Assessment System (ICDAS), while oral hygiene was evaluated using the Plaque Index (PI), Gingival Index (GI), and Bleeding on Probing (BOP).