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Background: admission to a Geriatric Evaluation and Management Unit (GEMU) can optimise a patient's chance of functional recovery.
Objective: to evaluate the ability of several commonly used frailty and functional decline indices to predict GEMU outcomes, both at discharge and at 6 months.
Design: prospective, observational study.
Setting And Participants: consecutive GEMU patients aged ≥70 years.
Methods: patients were classified as 'frail' or 'at high risk of functional decline' using several frailty and functional decline instruments. Predictive ability was evaulated using logistic regression and area under receiver operator characteristic (ROC) curves (auROC).
Results: a total of 172 patients were included. Frailty prevalence varied from 24 to 94% depending on the instrument used. Several instruments predicted patients at risk of poor outcome, including the Frailty Index of Accumulative Deficits (FI-CD), Fried's Cardiovascular Health Study index, the Study of Osteoporotic Fractures index, an adapted Katz score of activities of daily living (ADL), Instrumental ADL, the Score Hospitalier d'Evaluation du Risque de Perte d'Autonomie (SHERPA) and grip strength [odds ratio (OR) range of 2.06-6.47]. Adequate discriminatory power for discharge outcome was achieved by the FI-CD (auROC = 0.735, P < 0.001) and an adapted Katz score (auROC = 0.704, P = < 0.001). The FI-CD also showed adequate discriminatory power for a poor 6-month outcome (auROC = 0.702, P < 0.001).
Conclusion: frailty and functional decline instruments can predict older patients at risk of poor outcome. However, only the FI-CD showed adequate discriminatory power for outcome prediction at both follow-up time-points.
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http://dx.doi.org/10.1093/ageing/aft181 | DOI Listing |
Nutr J
September 2025
Department of Geriatric, The First Hospital of China Medical University, No. 155 Nanjing North Street, Heping Ward, Shenyang, 110001, China.
Objective: This study analyzed data from the US population to examine how oral microbiome diversity and diet quality individually and synergistically affect frailty.
Methods: This study included 6,283 participants aged 20 years or older from the 2009-2010 and 2011-2012 NHANES cycles. A frailty index (FI) consisting of 36 items was developed, with items related to nutritional status excluded.
Eur J Vasc Endovasc Surg
September 2025
Department of Surgery, Division of Vascular Surgery, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. Electronic address:
Objective: Despite the growing number of vascular interventions performed in elderly patients, the functional outcomes regarding frailty remain unclear. This study aimed to evaluate and compare the short term functional outcomes in pre-operative frail vs. non-frail patients following open vs.
View Article and Find Full Text PDFAgeing Res Rev
September 2025
University of Antwerp - Faculty of Medicine and Health Sciences - Department of Rehabilitation Sciences and Physiotherapy - Research Group MOVANT, Antwerp, Belgium; Vrije Universiteit Brussel - Faculty of Physical Education and Physiotherapy - Department Physiotherapy, Human Physiology and Anatomy -
Introduction: Frailty in older adults impairs Activities of Daily Living (ADL). While exercise interventions improve factors like muscle strength and physical function, their direct impact on ADL ability is inconsistent. This review aims to assess the effectiveness of exercise on ADL ability, identify the most beneficial interventions, and explore mediators.
View Article and Find Full Text PDFClin Neurol Neurosurg
September 2025
Department of Internal Medicine, Baylor Scott and White Health, Temple, TX, USA.
Background: Carotid artery stenosis prevalence increases with age, and carotid endarterectomy (CEA) is a possible treatment option. However, nonagenarians are at high risk of experiencing postoperative complications and are often not considered surgical candidates. We aimed to identify risk factors associated with postoperative myocardial infarction (MI), stroke, and death within 30 days for nonagenarians undergoing CEA and to analyze the predictive ability of modified frailty indices (mFI) in predicting adverse outcomes for this population.
View Article and Find Full Text PDFAnn Med
December 2025
School of Acupuncture-Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Background: To review the biological functions of ergothioneine (ERGO), its correlation with plasma levels in cognitive frailty, and research progress in treating frailty and cognitive impairment, with the aim of providing a reference for ERGO application in cognitive frailty treatment.
Methods: A comprehensive review of existing literature on ERGO's chemical structure, sources, antioxidant and anti-inflammatory effects, and its role in cognitive frailty was conducted. Clinical trial data and metabolomic studies were also analyzed to understand ERGO's therapeutic potential.