Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: Functional magnetic resonance imaging is sensitive to the variation in language network patterns. Large populations are needed to rigorously assess atypical patterns, which, even in neurological populations, are a minority.
Methods: We studied 220 patients with focal epilepsy and 118 healthy volunteers who performed an auditory description decision task. We compared a data-driven hierarchical clustering approach to the commonly used a priori laterality index (LI) threshold (LI < 0.20 as atypical) to classify language patterns within frontal and temporal regions of interest. We explored (n = 128) whether IQ varied with different language activation patterns.
Results: The rate of atypical language among healthy volunteers (2.5%) and patients (24.5%) agreed with previous studies; however, we found 6 patterns of atypical language: a symmetrically bilateral, 2 unilaterally crossed, and 3 right dominant patterns. There was high agreement between classification methods, yet the cluster analysis revealed novel correlations with clinical features. Beyond the established association of left-handedness, early seizure onset, and vascular pathology with atypical language, cluster analysis identified an association of handedness with frontal lateralization, early seizure onset with temporal lateralization, and left hemisphere focus with a unilateral right pattern. Intelligence quotient was not significantly different among patterns.
Interpretation: Language dominance is a continuum; however, our results demonstrate meaningful thresholds in classifying laterality. Atypical language patterns are less frequent but more variable than typical language patterns, posing challenges for accurate presurgical planning. Language dominance should be assessed on a regional rather than hemispheric basis, and clinical characteristics should inform evaluation of atypical language dominance. Reorganization of language is not uniformly detrimental to language functioning.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209919 | PMC |
| http://dx.doi.org/10.1002/ana.24015 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Opioid agonist therapy for opioid use disorder in primary versus specialty care.
Cochrane Database Syst Rev
September 2025
Department of Family Medicine, University of Alberta, Edmonton, Alberta, Canada.
Background: Opioid use disorder (OUD) is commonly treated in specialized care settings with long-acting opioid agonists, also known as opioid agonist therapy, or OAT. Despite the rise in opioid use globally and evidence for a 50% reduction in mortality when OAT is employed, the proportion of people with OUD receiving OAT remains small. One initiative to improve the access and uptake of OAT could be to offer OAT in a primary care setting; primary care clinics are more numerous, might reduce the visibility and potential stigma of receiving treatment for OUD, and may facilitate the care of other medical conditions that are unrelated to OUD.
View Article and Find Full Text PDFThe Noor Project: fair transformer transfer learning for autism spectrum disorder recognition from speech.
Front Digit Health
August 2025
iBUG - Intelligent Behaviour Understanding Group, Imperial College London, London, United Kingdom.
Early detection is crucial for managing incurable disorders, particularly autism spectrum disorder (ASD). Unfortunately, a considerable number of individuals with ASD receive a late diagnosis or remain undiagnosed. Speech holds a critical role in ASD, as a significant number of affected individuals experience speech impairments or remain non-verbal.
View Article and Find Full Text PDFAphasia Leading to the Diagnosis of Myotonic Dystrophy Type 1: A Case Report.
Cureus
July 2025
Internal Medicine, National Center for Geriatrics and Gerontology, Obu, JPN.
Myotonic dystrophy type 1 (DM1) is a multisystem autosomal dominant disorder primarily characterized by myotonia and distal muscle weakness. Central nervous system (CNS) involvement, including cognitive, executive, and emotional dysfunctions, is increasingly being recognized; however, language impairment as an initial presentation is rare. A 50-year-old right-handed woman with a six-month history of progressive word-finding difficulty, vague speech, and social withdrawal was referred for evaluation.
View Article and Find Full Text PDFNoonan Syndrome and Rett Syndrome in An 8-Year-Old Girl With A Tectal Neoplasm.
JCEM Case Rep
October 2025
Department of Pediatrics, Rhode Island Hospital/Hasbro Children's, Brown University Health, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.
Individuals with Noonan syndrome (NS) are predisposed to hematologic cancers, solid tumors, and low-grade gliomas. We report an 8-year-old girl originally referred at age 14 months for short stature, developmental delay, and failure to thrive who was subsequently found to have pathogenetic variants both in and Family history included a maternal half-sister with NS and a mother carrying the mutation. Familial single-gene testing showed a heterozygous pathogenic variant in (c.
View Article and Find Full Text PDFCross-Linguistic Transfer in Vietnamese-English Speech.
Lang Speech Hear Serv Sch
September 2025
Children's Voices Centre, Charles Sturt University, Bathurst, New South Wales, Australia.
Purpose: Typically developing multilingual children's speech may include mismatches and phonological patterns that are atypical in monolingual peers. One possible reason for mismatches is cross-linguistic transfer, when structures unique to one language are used while speaking another language. This study explored cross-linguistic transfer in Vietnamese-English-speaking children's and adults' speech at phoneme and syllable levels.
View Article and Find Full Text PDF