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Article Abstract
Triazacryptand (TAC)-based fluorescent K sensors have broad biomedical utility, yet their advancement has been hindered because of their challenging synthesis. Herein, an efficient synthesis is reported that delivers a didesmethyl tri-azacryptand (ddTAC) K sensor in twofold fewer steps and ninefold higher overall yield than the original TAC synthesis. Our synthesis utilizes a C-O dianionic oxidative macrocyclization and reports new examples of aminoarylations and a microwave route to xanthythilium chromophores. The K sensitivity and selectivity of the ddTAC-based sensor are comparable to the TAC-based sensor.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729919 | PMC |
| http://dx.doi.org/10.1002/ejoc.201001450 | DOI Listing |
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