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Using prospective longitudinal data from 198 very preterm and 70 full term children, this study characterised the memory and learning abilities of very preterm children at 7 years of age in both verbal and visual domains. The relationship between the extent of brain abnormalities on neonatal magnetic resonance imaging (MRI) and memory and learning outcomes at 7 years of age in very preterm children was also investigated. Neonatal MRI scans were qualitatively assessed for global, white-matter, cortical grey-matter, deep grey-matter, and cerebellar abnormalities. Very preterm children performed less well on measures of immediate memory, working memory, long-term memory, and learning compared with term-born controls. Neonatal brain abnormalities, and in particular deep grey-matter abnormality, were associated with poorer memory and learning performance at 7 years in very preterm children. Findings support the importance of cerebral neonatal pathology for predicting later memory and learning function.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965650 | PMC |
http://dx.doi.org/10.1080/09658211.2013.809765 | DOI Listing |
Nature
September 2025
Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, USA.
Nature
September 2025
Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Loss-of-function variants in the lipid transporter ABCA7 substantially increase the risk of Alzheimer's disease, yet how they impact cellular states to drive disease remains unclear. Here, using single-nucleus RNA-sequencing analysis of human brain samples, we identified widespread gene expression changes across multiple neural cell types associated with rare ABCA7 loss-of-function variants. Excitatory neurons, which expressed the highest levels of ABCA7, showed disrupted lipid metabolism, mitochondrial function, DNA repair and synaptic signalling pathways.
View Article and Find Full Text PDFNeurosci Lett
September 2025
Zonguldak Bülent Ecevit University Faculty of Medicine, Department of Physiology, Zonguldak, Turkey.
Stress triggers neuroendocrine and physiological changes, often resulting in cognitive impairments and heightened anxiety. This study aims to investigate the effects of acute stress and epinephrine administration on learning, memory, and anxiety-like behavior, as well as their impact on proinflammatory cytokines, neurogranin expression, and brain energy metabolism. In this study, three experimental groups were established, each comprising eight rats: control, acute stress, and acute stress combined with epinephrine.
View Article and Find Full Text PDFJ Affect Disord
September 2025
The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China; Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China. Electronic address:
Background: Transcranial direct current stimulation (tDCS), a non-invasive brain stimulation method, can improve depressive symptoms by applying weak electric direct currents to the scalp. This study aimed to evaluate the efficacy and safety of adjunctive tDCS for adolescents with first-episode major depressive disorder (FE-MDD).
Methods: This double-blind, randomized, sham-controlled trial (RCT) was conducted between January 3, 2024, and August 24, 2024.
Comput Methods Programs Biomed
September 2025
eXiT Research Group, Universitat de Girona (UdG), EPS - Edifici P-IV, Carrer Universitat de Girona, 6, Girona, 17003, Catalunya, Spain.
Background And Objective: Hybrid forecasting methods aim to overcome the limitations of classical statistical approaches and deep learning models. While statistical methods provide interpretability, they often lack predictive power. Conversely, deep learning models achieve high accuracy but act as "black boxes.
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