Peroxynitrite activity of hemin-functionalized reduced graphene oxide.

Analyst

Institut de Recherche Interdisciplinaire (IRI, USR 3078), Université Lille1, Parc de la Haute Borne, 50 Avenue de Halley, BP 70478, 59658 Villeneuve d'Ascq, France.

Published: August 2013


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Conducting interfaces modified with reduced graphene oxide (rGO) have shown improved electrochemical response for different analytes. The efficient formation of functionalized rGO based materials is thus of current interest for the development of sensitive and selective biosensors. Herein, we report a simple and environmentally friendly method for the formation of a hemin-functionalized rGO hybrid nanomaterial that exhibits remarkable sensitivity to peroxynitrite (ONOO(-)) in solution. The hemin-functionalized rGO hybrid nanomaterial was formed by mixing an aqueous solution of graphene oxide (GO) with hemin and sonicating the suspension for 5 h at room temperature. In addition to playing a key role in biochemical and electrocatalytic reactions, hemin has been proven to be a good reducing agent for GO. The sensitivity of the peroxynitrite sensor is ≈7.5 ± 1.5 nA mM(-1) with a detection limit of 5 ± 1.5 nM.

Download full-text PDF

Source
http://dx.doi.org/10.1039/c3an00678fDOI Listing

Publication Analysis

Top Keywords

graphene oxide
12
reduced graphene
8
hemin-functionalized rgo
8
rgo hybrid
8
hybrid nanomaterial
8
sensitivity peroxynitrite
8
peroxynitrite activity
4
activity hemin-functionalized
4
hemin-functionalized reduced
4
oxide conducting
4

Similar Publications

Ultrasmall MoC-MoO Heterojunction Coupled with Nitrogen-Doped Reduced Graphene for Boosting the Deep Oxidative Desulfurization of Fuel Oils.

Langmuir

September 2025

Engineering Technology Research Center of Preparation and Application of Industrial Ceramics of Anhui Province, Engineering Research Center of High-frequency Soft Magnetic Materials and Ceramic Powder Materials of Anhui Province, School of Chemistry and Material Engineering, Chaohu University, Chaoh

In this study, a MoC-MoO@NCrGO-900 composite catalyst comprising two-dimensional nitrogen-doped reduced graphene oxide (NCrGO) and ultrasmall molybdenum carbide-molybdenum dioxide (MoC-MoO) heterojunctions was synthesized. The optimized catalyst exhibited an outstanding oxidative desulfurization (ODS) performance. Specifically, a model oil containing 4000 ppm sulfur was completely desulfurized within 30 min, with a desulfurization efficiency of 98.

View Article and Find Full Text PDF

Carbon-based nanoparticles possess distinctive chemical, physical, and biological characteristics that render them suitable for biomedical uses. This paper reviews recent advancements in carbon-based nanomaterial (CBs) synthesis methods, emphasizing the importance of careful modification for biomedical uses, particularly in the passivation of drugs and chemicals on their surfaces. This review article examines information from 2021-2024 regarding carbon-based nanoparticles and the biomedical uses of graphene, fullerene, carbon nanotubes, nano horns, nanodiamonds, quantum dots, and graphene oxide.

View Article and Find Full Text PDF

Graphene oxide and its derivatives have unique physical and chemical properties with applications in many different fields. However, their biological effects and mechanisms of intracellular toxicity have not been completely clarified. In this study, we investigated the cytotoxic and autophagic activities of graphene oxide and its derivatives in A549 human lung carcinoma cells.

View Article and Find Full Text PDF

A mannose-functionalized carbon dot and boronic acid-graphene oxide nanocomposite fluorescent probe for detection.

Anal Methods

September 2025

State Key Laboratory of Advanced Papermaking and Paper-based Materials, South China University of Technology, 381 Wushan Road, Guangzhou 510640, China.

Current detection methods for often suffer from lengthy procedures, significant technical limitations, high probe costs, and poor long-term storage stability. Herein, an "on-off-on" fluorescent probe is developed based on mannose-lectin recognition for the rapid and quantitative detection of . The probe utilizes mannose-grafted carbon dots (g-CDs-M), which specifically recognize through interaction with lectins on its surface.

View Article and Find Full Text PDF

Confronting the dual challenges of carbon neutrality and sustainable energy, photocatalytic CO reduction requires precise control over product selectivity. This study demonstrates that surface hydroxyl (-OH) density serves as a molecular switch for reaction pathways in graphene oxide/cobalt tetraphenylporphyrin (GO/CoTPP) hybrids. By tuning the reduction degree of GO supports via gradient hydrazine hydrate treatment (0-85%), we constructed catalysts with controlled -OH concentrations.

View Article and Find Full Text PDF