Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
In the present work, we indicate that copper is involved in the senescence of human diploid fibroblasts and we describe mechanisms to explain it. Using different techniques, we show for the first time an accumulation of copper in cells during replicative senescence. This accumulation seems to be co-localized with lipofuscin. Second, we observed that an incubation of cells with copper sulfate induced oxidative stress, antioxidant response and premature senescence. Antioxidant molecules reduced the appearance of premature senescence. Third, we found that Nrf2 transcription factor was activated and regulated the expression of genes involved in antioxidant response while p38(MAPK) regulated the appearance of premature senescence.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824981 | PMC |
| http://dx.doi.org/10.1007/s11357-013-9521-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Clinical and molecular insights into Wiedemann-Rautenstrauch syndrome: A case report and genetic analysis of the c.2707G > A variant in the POLR3A gene.
Exp Gerontol
September 2025
Grupo de Investigación en Neurosciencias y Muerte Celular, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia; Departamento de Pediatría, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia.
Wiedemann-Rautenstrauch syndrome (WRS) is a rare neonatal progeroid disorder primarily associated with pathogenic variants in POLR3A. However, the pathogenicity of certain variants remains unclear. Here, we report a WRS case carrying the POLR3A c.
View Article and Find Full Text PDFSpecific features of immune ageing are detected in the earliest stages in rheumatoid arthritis development.
EBioMedicine
September 2025
Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, University of Birmingham, Birmingham, UK; MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham, UK; NIHR Birmingham Biomedical Research Centre, University Hospita
Background: Rheumatoid arthritis is an age-related disease displaying features of an aged immune system. This study aims to determine premature presence of immune ageing in the early stages of RA development, including in patients with clinically suspected arthralgia and undifferentiated arthritis.
Methods: We recruited 224 participants: 69 healthy controls (mean age 57.
Objectives: This narrative review identifies pitfalls in managing constipation in older adults and provides evidence-based recommendations to avoid them.
Methods: A selective literature search was conducted across electronic databases (PubMed, MEDLINE, Embase, and Cochrane Library) to identify relevant publications on constipation management in older adults. Randomized controlled trials, meta-analyses, systematic reviews, evidence-based clinical practice guidelines, and selected expert consensus statements and narrative reviews were included.
Effects of combined aerobic-resistance training on health-related quality of life and stress in sedentary adults.
Front Aging
August 2025
Department of Sports and Well-being, Polytechnic University of Castelo Branco, Castelo Branco, Portugal.
Introduction: Poor quality of life and psychological stress have been associated with worse clinical outcomes, including anxiety and depression disorders, cardiovascular diseases, metabolic syndrome, type 2 diabetes, and premature mortality. Evidence suggested that physically active adults were more likely to report better quality of life and increased capacity to deal with stress, compared to their sedentary peers. This study examines the effects of 16 weeks of combined aerobic and resistance exercise training on health-related quality of life (HRQoL) and stress levels in sedentary adults.
View Article and Find Full Text PDFImmunosenescence in multiple sclerosis: New insights and clinical implications.
Mult Scler
September 2025
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genoa, Italy; Department of Research, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Aging is associated with profound changes in cellular function (senescence) and affects various tissues and systems, including the immune system (immunosenescence). Despite the increasing average age of individuals with multiple sclerosis (MS), little is known about what happens to the immune system of aging people with MS or about the impact of immunomodulatory and immunosuppressive treatments for MS on the aging immune system. In this topical review, we discuss the concepts of physiological cellular senescence and immunosenescence, and we review the latest available data on immunosenescence in MS.
View Article and Find Full Text PDF