Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jacc.2013.02.038 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Target the Heart: A New Axis of Alzheimer's Disease Prevention.
J Dement Alzheimers Dis
June 2025
Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02912, USA.
Background/objective: Cyclosporine A and other calcineurin inhibitors have been identified as prospective treatments for preventing Alzheimer's disease. We previously found that calcineurin inhibitors elicit a unique behavioral profile in zebrafish larvae, characterized by increased activity, acoustic hyperexcitability, and reduced visually guided behaviors. Screening a large library of FDA-approved compounds using Z-LaP Tracker revealed that some heart medications produce a similar behavioral profile, suggesting these drugs may exert calcineurin-inhibitor-like effects relevant to prevent-ing or ameliorating Alzheimer's disease.
View Article and Find Full Text PDFPluripotent Cinnamic Acid and Valproic Acid Hybrid Molecules Designed as Strong Anti-inflammatory and Anti-hyperlipidemic Compounds.
Med Chem
September 2025
Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, Thessaloniki 54124, Greece.
Introduction: Inflammation and oxidative stress are considered main pathophysiological factors for neuronal and cardiovascular diseases, also leading to the impairment of main cellular metabolic pathways. Promotion of hyperlipidemia is also the result of inflammatory and oxidative (ROS production) processes. Additionally, compounds of medicinal interest like valproic and caffeic acids and amino acids like proline and tyrosine have shown antiinflammatory and cellular protective potency.
View Article and Find Full Text PDFInsights into Silica-Induced Lung Fibrosis: Fibrotic Gene Signatures, Pathways, and Therapeutic Opportunities.
Int Arch Allergy Immunol
September 2025
Silica exposure is a significant environmental hazard linked to lung inflammation and fibrosis. This study utilized in-silico analysis of publicly available transcriptomic datasets (GSE250537 and GSE142446) from silica-exposed Fischer 344 rats to investigate molecular pathways and potential therapeutic targets. Rats were exposed to crystalline silica via inhalation, and transcriptomic data from lung and blood samples were analyzed at four post-exposure intervals (1-day, 3-month, 6-month, and 9-month).
View Article and Find Full Text PDFThe local application of a 1% simvastatin gel improves bone regeneration in osteoporotic mandibular defects: a rat model study.
Ann Med Surg (Lond)
September 2025
Department of Oral and Maxillofacial Surgery, Tishreen University Hospital, Lattakia, Syria.
Background: The purpose of this study is to evaluate the effectiveness of simvastatin in the bone formation of osteoporotic mandible in the rat model.
Methods And Materials: Eight Wistar male rats at the age of 6 months, with a weighted average of 250-300 grams, were purchased from the Atomic Energy Authority in Damascus (Syria). Osteoporosis was induced through bilateral orchiectomy, a procedure that involves the removal of the testes, under anesthesia with a combination of ketamine and xylazine.
Age-specific protective effects of statins against cirrhosis in patients with chronic liver enzyme elevation associated with metabolic dysfunction: a retrospective cohort study of electronic health records.
EClinicalMedicine
September 2025
Gastroenterology, Duke University Medical Center, Durham, NC, USA.
Background: The hepatoprotective effects of statins in chronic liver diseases are well-documented; however, variation by age, sex, and formulation remains unclear. The optimal regimen for cirrhosis prevention has yet to be defined. We aimed to address this knowledge gap.
View Article and Find Full Text PDF