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Artefactually low creatinine by Beckman Coulter enzymatic method due to immunoglobulin M paraprotein interference.
Ann Clin Biochem
November 2023
Te Whatu Ora - Health New Zealand Waitaha Canterbury, Christchurch, New Zealand.
An 81-year-old man was admitted to hospital with symptomatic coronavirus disease (COVID-19) infection. He had a background of progressive chronic inflammatory demyelinating polyneuropathy associated with Waldenstrom's macroglobulinaemia. His plasma creatinine on four separate samples was inconceivably low (all ≤13 μmol/L), as measured by a Beckman Coulter enzymatic assay) after being 72 μmol/L 3 months earlier.
View Article and Find Full Text PDFFalsely low serum creatinine caused by immunoglobulin M paraprotein interference with enzymatic method.
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Evaluation of SARS-CoV-2 Serological Testing in Patients with Multiple Myeloma and Other Hematologic Malignancies on Monoclonal Antibody Therapies.
Diagnostics (Basel)
November 2020
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Background: Patients with hematological malignancies (HM), including multiple myeloma (MM), frequently suffer from immune deficiency-associated infectious complications because of both the disease and the treatment. Alarming results from China and the UK confirm the vulnerability of HM patients to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-driven coronavirus disease 2019 (COVID-19). Given that the immunoassay interference from the endogenous monoclonal immunoglobulin (M paraprotein) and treatment antibodies continually challenges the MM management, it is critical to evaluate the SARS-CoV-2 serology tests for suspected interference/cross-reactivity.
View Article and Find Full Text PDFFalsely Elevated Plasma Creatinine Due to an Immunoglobulin M Paraprotein.
Am J Kidney Dis
November 2016
Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO. Electronic address:
The most common method for measuring plasma creatinine is based on its reaction with picric acid. However, enzymatic methods are becoming more popular due to improved specificity. We present a case of falsely elevated plasma creatinine values obtained by an enzymatic method that turned out to be due to a monoclonal immunoglobulin M (IgM) paraprotein.
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