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http://dx.doi.org/10.1016/j.healun.2012.12.003 | DOI Listing |
Circ Res
August 2025
Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Baltimore, MD.
Sleep irregularity, characterized by inconsistent sleep patterns from day to day, has become increasingly prevalent in today's 24/7 society. As a key component of multidimensional sleep health, the potential impact of sleep irregularity on cardiometabolic disease and mortality has recently received attention in research. In this review, we summarize the current evidence from epidemiological, clinical, and mechanistic studies to highlight the role of sleep irregularity in obesity, metabolic syndrome, diabetes, cardiovascular disease, and mortality.
View Article and Find Full Text PDFJ Cardiovasc Dev Dis
July 2025
Department of Cardiology, National University Heart Centre, Singapore 119228, Singapore.
Background/objectives: Left atrial function can be a tool for risk stratification for hypertrophic cardiomyopathy (HCM). Over the past decade, there has been growing interest in the application of strain analysis for earlier and more accurate prediction of cardiovascular disease prognosis. This study aimed to investigate the performance of left atrial strain analysis compared to conventional left atrial measures in predicting clinical outcomes in Asian patients with HCM.
View Article and Find Full Text PDFIndian J Tuberc
July 2025
Department of Dermatology, Venereology and Leprosy, Government Medical College, Patiala, India.
Introduction: Tuberculosis (TB) remains a significant global health issue, ranking as the 13th leading cause of death worldwide. Management of tuberculosis requires administration of multiple drugs for varied duration which increases the risk of developing adverse reactions. Among various adverse reactions are cutaneous adverse reactions (CARs) which can be immune mediated or non immune mediated.
View Article and Find Full Text PDFHead Neck
July 2025
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Background: Nuclear protein in testis (NUT) carcinomas (NCs) are rare, clinically aggressive tumors with characteristic translocation involving NUTM1 and BRD4 genes. While NCs are generally characterized by undifferentiated basaloid cells with focal/abrupt squamous differentiation, tumoral heterogeneity remains unexplored. This may have therapeutic implications as NC frequently develops drug resistance and metastasis.
View Article and Find Full Text PDFAdv Sci (Weinh)
June 2025
Department of Orthopaedics and Traumatology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.
Inflammation is a hallmark of intervertebral disc degeneration (IVDD) characterized by immune cell infiltration and cytokine secretion. Stage-specific transcriptomic analyses of IVDD via single-cell RNA sequencing (scRNA-seq) have primarily focused on nucleus pulposus cell phenotypes but not immune subpopulations. In other disease contexts, integrating genome-wide association studies (GWAS) with scRNA-seq data has provided insights on pathomechanisms in relation to specific cellular subpopulations via single-cell disease relevance scores (scDRS).
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