Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Studies were conducted into the activities of calcium, magnesium, and sodium-potassium ATPase as well as into crude protein levels in homogenate and cell fractions of brain of two foetuses, aged 111 days, and of two piglets each, aged two days or nine weeks. The average brain-borne crude protein percentages were 6.55 in the foetuses, 7.25 in the two-day piglets, and 9.60 in the nine-week piglets. Calcium, magnesium, and sodium-potassium ATPase activities, related to one gram of fresh brain mass, were found to go up along with growing age. Highest relative percentages of sodium-potassium ATPase were recordable from homogenate and from the mitochondrial and microsomal fractions of the foetuses. Certain quantitative differences were obtained from using calcium, magnesium, sodium, and potassium ions to stimulate ATPase in the fractions of cell nuclei, mitochondria, and microsomes. The optimum temperature for magnesium and sodium-potassium ATPase in homogenate and in the mitochondrial fraction of brain was 45 degrees C.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Strigolactone and Hydrogen Sulfide Regulate Carbohydrate Metabolism and Ion Homeostasis Through H-ATPase Activity and K Retention Under Salt Stress.
Physiol Plant
August 2025
Department of Biology, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia.
This study investigates the roles of strigolactones (SL) and endogenous hydrogen sulfide (HS) in regulating physiological processes in tomato seedlings under NaCl-induced stress. Exposure of the seedlings to 100 mM NaCl stress reduced K content by 21% while increasing Na accumulation by 69%, disrupting the K/Na ratio and impairing H-ATPase activity. However, the application of SL improved H-ATPase activity and K uptake and reduced Na accumulation.
View Article and Find Full Text PDFGenetic Insights into Hemiplegic Migraine: Whole Exome Sequencing Highlights Vascular Pathway Involvement via Association Analysis.
Genes (Basel)
July 2025
Genomics Research Centre, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, 60 Musk Ave, Kelvin Grove, QLD 4059, Australia.
: Hemiplegic migraine (HM) is a rare and severe subtype of migraine with a complex genetic basis. Although pathogenic variants in , , and explain some familial cases, a significant proportion of patients remain genetically undiagnosed. Increasing evidence points to an overlap between migraine and cerebral small vessel disease (SVD), implicating vascular dysfunction in HM pathophysiology.
View Article and Find Full Text PDFThe role of Na,K‑ATPase in lung diseases (Review).
Mol Med Rep
November 2025
Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
Na,K‑ATPase, commonly referred to as the sodium pump, is known for its essential function as an ion pump, which is key for transporting Na and K across plasma cell membranes. Additionally, Na,K‑ATPase has multiple biological functions, independent of ion pumping, which are involved in regulating cell proliferation, apoptosis, differentiation and other processes associated with the development and progression of various diseases; particularly cancer, cardiovascular diseases, nervous system diseases, kidney diseases and lung diseases. As a potential therapeutic target, Na,K‑ATPase may represent a novel strategy for treating these diseases in the future.
View Article and Find Full Text PDFAnalysis of the Proteome and Biochemistry of Venom from , a Scorpion That Can Be Involved in Severe Envenomation Cases in Brazil.
Toxins (Basel)
August 2025
Institute of Biosciences, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil.
In Brazil, the annual scorpion sting cases surpass those of other neglected tropical diseases, highlighting a significant public health issue. The severity of scorpion envenomation relates to the venom's rapid action, complex composition, species identification challenges, and limited antivenom availability. This work aimed to characterize the venom of through proteomic, enzymatic, and biological analyses while also assessing its reactivity to anti-scorpion antivenom.
View Article and Find Full Text PDFMediators of the stimulatory effect of S1P on colonic Na+/K+ ATPase.
PLoS One
August 2025
Department of Biology, Faculty of Arts & Sciences, American University of Beirut, Beirut, Lebanon.
The Na ⁺ /K ⁺ ATPase, commonly known as the Na ⁺ /K⁺ pump, plays a crucial role in colonic sodium and water transport, inducing diarrhea or constipation. Inflammatory bowel disease is often associated with diarrhea and elevated levels of sphingosine-1-phosphate (S1P), suggesting a potential relationship between the pump and S1P. This study investigated the effects of S1P on colonic Na ⁺ /K ⁺ ATPase using Caco-2 cells as a model and the S1P analogue used in the treatment of multiple sclerosis, FTY720P.
View Article and Find Full Text PDF