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Federal policy toward health information exchange (HIE), the electronic transfer of patient data across organizations, has evolved to support two forms-push, or point-to-point data transmission, and pull, or multisource data aggregation. HIE usage is associated with user satisfaction, but existing quantitative research is limited to settings where only pull HIE is available. To address this gap, we surveyed 99 physicians regarding usage of and satisfaction with push HIE and pull HIE available in their communities as well as effects of HIE on practice and overall HIE satisfaction. In five of nine measures, respondents reported being very satisfied with push HIE more often than pull HIE (p < 0.05). Physicians were at least four times as likely to report being very satisfied with HIE overall if they were pediatricians, were very satisfied with push HIE, or noted that HIE improved their access to complete information. Findings have implications for HIE implementation and policy.
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Br J Haematol
September 2025
Department of Hematology, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan.
The efficacy of ciclosporin (CsA) to treat transfusion-independent non-severe aplastic anaemia (TI-NSAA) has not yet been systematically evaluated. We conducted a prospective trial in patients with TI-NSAA treated with CsA monotherapy. CsA (3.
View Article and Find Full Text PDFBiochem Pharmacol
September 2025
Department of Anesthesiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 XianXia Road, Shanghai 200336, China; Hongqiao International Institute of Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 XianXia Road, Shanghai 200336, China. El
Hypoxic-ischemic brain damage (HIBD) is a severe condition leading to extensive neuronal loss and functional impairments, representing a significant challenge in neonatal care. PFGA12, a peptide derived from fibrinogen alpha chain (FGA), which is notably downregulated in the umbilical cord blood of hypoxic-ischemic encephalopathy (HIE) infants. We demonstrate that PFGA12 significantly enhances cell viability and mitigates oxygen-glucose deprivation/reperfusion (OGD/R)-induced neuronal cell death.
View Article and Find Full Text PDFJAMIA Open
October 2025
Fetal-Neonatal Neuroimaging Developmental Science Center, Division of Newborn Medicine, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, United States.
Objectives: To develop a data harmonization framework for neonatal hypoxic-ischemic encephalopathy (HIE) studies and demonstrate its suitability for prognostic biomarker development.
Materials And Methods: Variables were first categorized by chronological stages and then by medical topics. We created a dictionary to harmonize variable names and value coding.
JAMA Health Forum
September 2025
Department of Health Policy and Management, School of Public Health, University of Maryland, College Park.
Importance: Access to and quality of care vary substantially by area socioeconomic status. Expanding hospital health information technology (HIT) adoption may help reduce these disparities, given hospitals' central role in serving underserved populations.
Objective: To examine variations in US hospital adoption of telehealth and health information exchange (HIE) functionalities by hospital service area (HSA) socioeconomic deprivation.
J Paediatr Child Health
September 2025
New Zealand Cerebral Palsy Register Te Rēhita a Hōkai Nukurangi Aotearoa, Health New Zealand/Te Whatu Ora, Starship Hospital, Auckland, New Zealand.
Background: In Aotearoa New Zealand (AoNZ), the cerebral palsy (CP) register (NZCPR) has collected national data since 2015. The dataset includes ethnicity and region of domicile; clinical characteristics; plus data on CP distribution and severity including GMFCS. Neonatal encephalopathy (NE) and hypoxic ischaemic encephalopathy (HIE) are potential causes of CP, so NZCPR data may assist prognostic counselling of whānau (family).
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