Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
We report a non-invasive mixed mucin-producing and squamous differentiated tumor of the uterine cervix. This tumor was composed of two cell types: mucin-producing cells and non-mucin-producing cells. These cells were intimately mixed with each other, and showed intraepithelial spreading. The mucin-producing cells showed signet-ring or columnar shapes, and were localized to the lower-to-upper epithelial layer. The non-mucin-producing cells had eosinophilic cytoplasms with a monotonous appearance through the epithelium. Mitosis was sometimes observed in both cell types. Immunohistochemically, both cell types were positive for p16(INK4A) . The non-mucin-producing cells were positive for p63 and 34βE12, suggesting squamous differentiation. Although most mucin-producing cells were p63(-) , a few of them were p63(+) and many 34βE12 immunoreactive cells were found in the mucin-producing cells. This tumor was adenosquamous carcinoma in situ.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1447-0756.2012.01904.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Appendiceal mucinous neoplasms: Optimizing treatment strategies based on clinical, histological, and molecular features.
World J Clin Oncol
August 2025
Division of Gastroenterologic Surgery, Department of Surgery, Tohoku Medical and Pharmaceutical University, Sendai 983-8536, Miyagi, Japan.
Appendiceal mucinous neoplasms (AMNs) are rare tumors originating from mucin-producing epithelial cells of the appendix. They can exhibit both benign and malignant behavior. They are often incidentally discovered during appendectomy.
View Article and Find Full Text PDFIdentification of biomarkers for gastrointestinal barrier injury and protective role of sodium butyrate in hypobaric hypoxia exposed rats.
Int Immunopharmacol
August 2025
Defence Institute of Physiology and Allied Sciences, Delhi 110054, India. Electronic address:
Individuals travelling to elevated altitudes are at a greater risk of developing acute mountain sickness and gastrointestinal problems due to hypoxic conditions. Exposure to high altitude hypoxia may result in injury that compromises intestinal barrier integrity, leading to increased permeability, inflammation and impaired nutrient absorption. Early detection of hypoxia induced gastrointestinal barrier injury is crucial for preventing complications such as sepsis, multiple organ failure and potentially fatal gastrointestinal bleeding.
View Article and Find Full Text PDFDiatomaceous Earth Supplementation as a Bioavailable Silicon Source Modulates Postprandial Lipid Metabolism in Healthy Female Rats.
Nutrients
July 2025
Departmental Section of Physiology, Pharmacy School, Complutense University of Madrid, 28040 Madrid, Spain.
Background/objectives: Diatomaceous earth (DE), a natural substance rich in amorphous silica and recognized as a food additive, is gaining attention as a dietary silicon supplement. However, its bioavailability and impact on lipid digestion and absorption remain poorly characterized. This study aimed to investigate silicon bioavailability after short-term DE supplementation and its effects on postprandial glycemia and triglyceridemia, the expression of lipid metabolism-related proteins, and the modulation of the intestinal mucosal barrier.
View Article and Find Full Text PDFUsing MUC2 mucin producing tumorigenic human goblet-like cells to uncover functional properties of the mucus barrier.
Gut Microbes
December 2025
Departments of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada.
Goblet cells are the guardians that produce MUC2 mucin that forms the protective mucus barrier as the first line of innate host defense against pathogen invasion while sustaining a healthy gut microbiota. Using an unbiased screen, we cloned a high LS174T colonic adenocarcinoma MUC2 mucin-producing goblet-like cell that revealed by whole genome sequencing, mutations that upregulated the expression of tumor suppressor , anterior gradient 2 () and mitogen-activated protein kinase kinases ( and ) genes that enhanced MUC2 biosynthesis and secretion. Hypersecretory () cells exhibited a phenotype characterized by high constitutive mRNA, upregulation of glycosyltransferases, and hypersecretion of sialylated and fucosylated MUC2 mucus enumerated by glycomics analysis.
View Article and Find Full Text PDFAcute Dermatotoxicity of Green-Synthesized Silver Nanoparticles (AgNPs) in Zebrafish Epidermis.
Toxics
July 2025
Department of Biological and& Environmental Sciences, Walter Sisulu University, P/B X1, Mthatha 5117, South Africa.
Silver nanoparticles (AgNPs), lauded for their unique antibacterial and physicochemical attributes, are proliferating across industrial sectors, raising concerns about their environmental fate, in aquatic systems. While "green" synthesis offers a sustainable production route with reduced chemical byproducts, the safety of these AgNPs for aquatic fauna remains uncertain due to nanoparticle-specific effects. Conversely, mast cells play crucial roles in fish immunity, orchestrating innate and adaptive immune responses by releasing diverse mediators and recognizing danger signals.
View Article and Find Full Text PDF