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Background: Surveillance systems often present data by means of summary measures, like age-standardised rates. In this study, we aimed at comparing information derived from commonly used measures of smoking with that presented in modified population pyramids (PPs), using the example of the diffusion of smoking in Italy over the past two decades.
Methods: Data were derived from four National Health Interview Surveys carried out in 1983, 1990 to 1991, 1999 to 2000, and 2004 to 2005. After computing both age-specific and age-standardised rates of current, former, and never smoking, we constructed modified PPs by stratifying the male and female populations according to smoking status and educational level.
Results: Modified PPs showed several features of the smoking epidemic in Italy that were not apparent from conventional surveillance techniques. First, they showed that the population of smokers is aging, with most current smokers in 2005 being males aged 25 to 39 and females aged 40 to 49, whereas in 1983 most smokers belonged to the youngest age groups. Second, they showed that in 2005 most smokers were found among subjects with middle and higher education, whereas two decades earlier most smokers were (male) subjects with the lowest education.
Conclusions: Modified PPs were able to show how absolute numbers of smokers were distributed by age and sex, how these numbers varied between population subgroups, and how they changed over time. PPs may help provide information on past and future trends in the absolute number of smokers and in their sociodemographic characteristics, which may be missed using only traditional surveillance methods.
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http://dx.doi.org/10.1186/1478-7954-10-23 | DOI Listing |
Curr Probl Surg
September 2025
Department of Gastrointestinal Surgery, Shandong Second Provincial General Hospital, Jinan, 250022, Shandong, China. Electronic address:
Langmuir
August 2025
School of Chemical Engineering, Changchun University of Technology, Changchun 130012, China.
Monodisperse porous polystyrene microspheres (PPS) and their derivatives were successfully fabricated via a two-step swelling polymerization approach combined with secondary cross-linking technology. Inspired by the surface morphology of algae, PPS and derivatives were subsequently modified using chitosan with different viscosities (CS-1 and CS-2), thereby constructing chitosan-functionalized PPS. By precisely adjusting the amounts of vinyl chloroacetate (VCA) and the cross-linker 1,4-bis(chloromethyl)benzene (XDC), the pore size of PPS and derivatives could be finely tuned within the range of 5-20 nm.
View Article and Find Full Text PDFBMJ Open
August 2025
Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Introduction: The immunocompromised host (ICH) is at increased risk for a range of opportunistic and healthcare-associated infections (OI/HAIs). With increased use of novel therapeutics and prolonged survival, the malignancy and transplant population is a particularly vulnerable and expanding subgroup. In the absence of a coordinated Australian infection surveillance programme, estimates of the prevalence of OI/HAIs for the high-risk ICH population are yet to be established.
View Article and Find Full Text PDFCancer Cell
June 2025
Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; RNA Discovery Center, UNC at Chapel Hill, Chapel Hill, NC, USA; Division of Hematology/Oncology, UNC at Chapel Hill, Chapel Hill, NC, USA. Electronic address:
Despite KRAS being the second most common KRAS mutation in cancer, no direct inhibitors targeting KRAS have been approved. RNA interference (RNAi) has faced numerous obstacles as cancer therapeutic, including the lack of cancer-specific tissue targeting, rapid oligonucleotide nuclease degradation, and clearance from circulation. Recently, the use of targetable ligands conjugated to chemically modified siRNAs have shown remarkable promise in circumventing these barriers.
View Article and Find Full Text PDFPolymers (Basel)
May 2025
Kunststofftechnik Paderborn, Paderborn University, 33098 Paderborn, Germany.
The degradation of polypropylene (PP) through thermal and mechanical stress, as well as the influence of oxygen, are unavoidable when processing on a co-rotating twin-screw extruder. In previous studies, a mathematical model was developed to predict the degradation while compounding on different twin-screw extruder sizes. Additionally, the examination of filled PPs was conducted.
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