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J Cell Mol Med
September 2025
Department of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
This study aims to assess whether endometriosis causally increases the risk of IBD through Mendelian randomisation (MR) analysis and to elucidate potential mechanisms using in vitro experiments. A two-sample Mendelian randomisation (MR) analysis was conducted using genome-wide association study datasets for endometriosis and IBD, including ulcerative colitis and Crohn's disease. Causal inference was assessed using inverse variance weighting, MR-Egger, and weighted median methods, with MR-PRESSO used to detect horizontal pleiotropy.
View Article and Find Full Text PDFJ Investig Med High Impact Case Rep
August 2025
Division of Gastroenterology, Texas Tech University Health Sciences Center, El Paso, USA.
Endometriosis is a gynecological condition that can manifest in pelvic and extra-pelvic sites, including the gastrointestinal tract. Cecal and appendiceal involvement is rare and can present as anemia, mimicking malignancy. The discussed case is of a 50-year-old female who presented with symptomatic anemia.
View Article and Find Full Text PDFJ Gastrointestin Liver Dis
August 2025
2nd Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Endometriosis is a medical condition where endometrial tissue and glands are found outside the uterine cavity: on ovaries, pelvic peritoneum, rectovaginal septum, bladder, bowel and more. The ectopic tissue is estrogen dependent and cause inflammation and immune response and is responsible for chronic pain, infertility and disability of these patients. Without a specific biomarker and with a wide range of symptoms, the diagnosis is often overlooked or delayed.
View Article and Find Full Text PDFDiagnostics (Basel)
July 2025
Regina Maria Hospital, 400117 Cluj-Napoca, Romania.
Endometriosis is a common gynecological disease that can occasionally be associated with malignant transformation. The most common site of malignant transformation is the ovary, but there can also be rare extragonadal endometriosis-associated malignancy sites, such as the intestines, rectovaginal septum, and abdominal wall. A low number of malignant degenerations of rectal endometriosis are described in the literature.
View Article and Find Full Text PDFInt J Gynecol Pathol
July 2025
Departments of Gynecology and Obstetrics.
A well-differentiated endometrioid carcinoma at the site of extra-uterine/ovarian endometriosis complicates the differentiation between an uncommon metastatic pattern from a corpus cancer and a synchronous primary tumor originating from adjacent endometriosis. Herein, we present 2 cases of well-differentiated uterine endometrial carcinoma metastasizing to the intestinal tract and uterosacral ligament, which were adjacent to surrounding endometriosis. Case 1: a well-differentiated endometrioid carcinoma was identified in the uterus and the uterosacral ligament.
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