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The evaluation of complex interventions, such as Single Event Multilevel Surgery (SEMLS) requires more than randomized controlled trials. Rehabilitation following SEMLS is prolonged and the outcomes of interest may not be apparent for 5 years or more after the surgery. We suggest long term, prospective cohort studies with objective outcome measures be recognized as of equal importance to randomized controlled trials. The evidence in support of instrumented gait analysis (IGA) is also reviewed. We suggest that clinical levels of evidence are not an appropriate method to evaluate a measurement tool. Specifically, IGA should be evaluated in terms of validity, reliability and cost effectiveness. We demonstrate that the use of IGA has improved medium and long term outcomes in ambulant children with cerebral palsy in a center where IGA has been used routinely both for planning SEMLS and for monitoring outcomes.
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http://dx.doi.org/10.1097/BPO.0b013e31825b6136 | DOI Listing |
Hum Brain Mapp
September 2025
Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Perinatal stroke is a vascular injury occurring early in life, often resulting in motor deficits (hemiplegic cerebral palsy/HCP). Comorbidities may also include poor neuropsychological outcomes, such as deficits in memory. Previous studies have used resting state functional MRI (fMRI) to demonstrate that functional connectivity (FC) within hippocampal circuits is associated with memory function in typically developing controls (TDC) and in adults after stroke, but this is unexplored in perinatal stroke.
View Article and Find Full Text PDFPhys Occup Ther Pediatr
September 2025
Department of Rehabilitation Sciences, Neurorehabilitation Technology Lab, KU Leuven Brugge, Bruges, Belgium.
Purpose: To explore the concurrent validity and responsiveness of the Wheelchair Skills Test-Questionnaire (WST-Q) caregiver proxy, and the inter- and intra-rater reliability of the Wheelchair Skills Test (WST) in children and young adults with cerebral palsy (CP).
Methods: Concurrent validity and responsiveness of the WST-Q caregiver proxy were assessed in 12 participants with CP (mean age 15 years; SD: 3 years 6 months); power wheelchair users. Concurrent validity of the WST-Q was determined using Pearson's correlation coefficients, and responsiveness with linear regression.
J Microbiol Immunol Infect
September 2025
Department of Pediatrics, MacKay Children's Hospital and MacKay Memorial Hospital, Taipei, Taiwan.
Background: Respiratory syncytial virus (RSV) is a leading cause of respiratory infections in infants and young children. The COVID-19 pandemic significantly disrupted global RSV epidemiology. This study aimed to investigate the impact of the pandemic on RSV epidemiology in northern Taiwan from 2018 to 2023.
View Article and Find Full Text PDFAcad Radiol
September 2025
Associate Professor of Radiology, University of Pennsylvania, Philadelphia, PA 19146 (S.J.). Electronic address:
Rationale And Objectives: To understand how an imperfect surrogate can lead to defensive medicine.
Materials And Methods: Historical analysis was performed on electronic fetal monitoring.
Results: Electronic Fetal Monitoring is an example of a flawed surrogate.
J Ayurveda Integr Med
September 2025
Regional Ayurveda Research Institute, Poojappura, Thiruvananthapuram, Kerala, 695012, India; Under Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, Govt. of India, New Delhi, India.
This case report is the description of a devastating illness, Progressive Bulbar Palsy (PBP) of a sixty-seven years old male patient. He presented with complaints of slurred speech, hearing impairment, generalised weakness of limbs, weakened grip to hold objects in hand, difficulty to walk with normal speed, frequent dizzy feeling while walking, severe fatigue, increased anger, heaviness of head, depression, anxiety, decreased memory and headache for 1 year. When he consulted conventional medicine, in Magnetic Resonance Imaging (MRI) of brain, only 'Partial empty sella' and age related mild cerebral atrophy was detected and the patient was diagnosed PBP clinically.
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