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The end-stage cardiomyopathy is an increasing worldwide problem. Cardiac transplantation lacks sufficient donors to treat all patients, and there is thus debate about alternative strategies. The use of left ventricular assist devices for long-term support is increasing with a positive impact on patient survival. Although there is an ongoing debate regarding the risks and benefits of maintaining pulsatile flow during long-term ventricular assist device support, there has been a significant move towards implantation of continuous flow devices due to the lower surgical morbidity and better long-term reliability of these pumps. The following is a review of the literature on continuous and pulsatile flow for long-term support. Starting from the definition of flow, we analyze the current evidence and consider gastrointestinal complications.
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http://dx.doi.org/10.1016/j.trre.2012.06.001 | DOI Listing |
Front Allergy
August 2025
Department of Surgery, University of Auckland, Auckland, New Zealand.
Allergic rhinitis (AR) and chronic rhinosinusitis (CRS) are common respiratory conditions that significantly impact patient health and contribute to substantial healthcare burdens. While conventional treatments offer symptom relief, many patients continue to experience persistent symptoms, side effects, or resistance to standard therapies. This highlights the growing need for novel, non-invasive, and sustainable therapeutic strategies to manage chronic airway inflammation.
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September 2025
Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, United States.
The frequency and severity of heat waves are expected to worsen with climate change. Exposure to extreme heat, or prolonged unusually high temperatures, are associated with increased morbidity and mortality. The fetus, infant, and young child are more sensitive to higher temperatures than older children and most adults given that they are rapidly developing.
View Article and Find Full Text PDFEClinicalMedicine
October 2025
Department of Cardiology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: The benefits of physiology-guided management in acute coronary syndrome (ACS) remain inconclusive due to limited evidence. In our FAVOR III China trial, a quantitative flow ratio (QFR)-based physiology-guided strategy versus standard angiography guidance improved the 1-year primary outcome among participants with coronary artery disease (CAD). We aimed to investigate, in a prespecified analysis, the outcomes of QFR-based physiological guidance in the FAVOR III China participants with low-risk ACS.
View Article and Find Full Text PDFSci Total Environ
September 2025
Department of Environmental Science, Aarhus University, Frederiksborgvej 399, 4000 Roskilde, Denmark; WATEC, Centre for Water Technology, Aarhus University, Ny Munkegade 120, 8000 Aarhus C, Denmark.
Treatment wetlands (TW) are a popular choice for decentralized wastewater treatment, with substantial documentation on their capacity to manage conventionally monitored pollutants. However, most insights into their effectiveness against emerging contaminants come from lab and mesocosm studies with a limited number of compounds, highlighting knowledge gaps in their performance at full scale. This study provides a first long-term, full-scale assessment of TW ability to remove a large number of organic micropollutants (OMPs) and manage antibiotic resistance under real-world conditions.
View Article and Find Full Text PDFJ Appl Physiol (1985)
September 2025
Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa, Iowa City, Iowa.
Long-term exercise training can attenuate sympathetic vasoconstriction in both resting and contracting skeletal muscle; however, the impact of an acute bout of exercise on vasoconstrictor responsiveness and the influence of aging is unknown. Therefore, we tested the hypothesis that an acute bout of exercise will blunt sympathetic-mediated vasoconstriction in resting and contracting skeletal muscle of young and older adults. Twenty-one adults (10 Young: 23±5 yr and 11 Older: 65±8 yr) performed a rest and a rhythmic handgrip exercise trial before and after either 30 minutes of cycling exercise (60-65% HRmax) or a time control period (seated rest).
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