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http://dx.doi.org/10.1684/ejd.2012.1803DOI Listing

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Superficial radiotherapy for non-melanoma skin cancer of the lip: a 44-year Italian experience.

J Dermatolog Treat

June 2020

Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Sezione Fotoradioterapia, UO Dermatologia, Milan, Italy.

Radiotherapy is a valuable therapeutic option for the treatment of non-melanoma skin cancer (NMSC) in the ageing population, in non-surgical candidates, or when the tumor is extensive or localized in a cosmetically sensitive area such as the lips. We report our 44-year experience in treating basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the vermilion lip using superficial radiotherapy. Forty-seven patients with biopsy-proven BCC or SCC of the lip were retrospectively reviewed.

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Background: The lip and surrounding perioral region are susceptible to non-melanoma skin cancer, but the distribution of basal cell and squamous cell carcinoma on the cutaneous and vermilion lips has not been fully elucidated.

Objective: To investigate the distribution of cutaneous and vermilion lip non-melanoma skin cancer and to better describe risk factors, anatomic location, treatment characteristics and oncologic outcomes.

Methods: A retrospective comparative case series of patients undergoing Mohs micrographic surgery (MMS) at a single academic centre for lip and perioral basal cell and squamous cell carcinoma was performed over a 5-year period.

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Although basal cell carcinoma (BCC) is a common skin tumor, very rare cases of BCC arising from upper vermilion mucosa of lip have been reported previously. This tumor basically, originates from pillar structures and the involvement of the vermilion lip contrasts this concept so it is devoid of hair follicles and sweat glands. The exact pathogenesis of vermilion lip BCC is not clear but it has been postulated that the neoplasm originates from the pluripotential epithelial cells of the oral mucosa and epidermis.

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We report a 21-year-old white woman who developed a large basal cell carcinoma (BCC) on her left upper vermilion border. Her mother and maternal grandmother both had a history of BCCs occurring in the same location. No documented BCC-related genetic disorder was suspected.

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