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http://dx.doi.org/10.1016/j.ajo.2012.03.016 | DOI Listing |
Rep Pract Oncol Radiother
August 2025
Department of Cancer Immunology, Chair of Medical Biotechnology, Poznan University of Medical Sciences, Poznan, Poland.
Initially, pseudogenes were considered to be "junk DNA", and their biological role was unclear. However, some of the pseudogenes are engaged in the process of cancerogenesis and perform essential functions in competing for endogenous ribonucleic acid (ceRNA) networks and competing for RNA binding proteins (RBPs). They either positively or negatively regulate gene expression and act as suppressive and oncogenic transcripts.
View Article and Find Full Text PDFMol Ther Methods Clin Dev
September 2025
Molecular Biology Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90095, USA.
X-linked agammaglobulinemia (XLA) is a rare inborn error of immunity caused by loss-of-function mutations in the gene encoding Bruton's tyrosine kinase (BTK). XLA patients lack mature B cells and have negligible antibody levels, leaving them susceptible to recurrent bacterial and chronic viral infections. Autologous hematopoietic stem cell gene therapy with gene-corrected HSC may serve as a promising treatment of XLA; this therapy would provide a one-time cure and would replace lifelong immunoglobulin replacement therapy.
View Article and Find Full Text PDFMol Ther Methods Clin Dev
September 2025
Versiti Blood Research Institute, Milwaukee, WI 53226, USA.
Plasminogen activator inhibitor-1 (PAI-1) deficiency is a rare disorder that causes moderate to severe bleeding and cardiac fibrosis, caused by mutation in the gene and no detectable circulating PAI-1 protein. There are currently no therapies that can effectively replace PAI-1 because the protein has a short half-life. An alternative approach to using recombinant protein is to endogenously increase circulating PAI-1 levels using mRNA therapy.
View Article and Find Full Text PDFPestic Biochem Physiol
November 2025
State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China; Hubei Hongshan Laboratory, Wuhan, Hubei, China; Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory, College of Plant, Science and Technology, Huazhong Agricultural
Galectins are a family of carbohydrate-binding proteins known to maintain intestinal microbiota homeostasis. Emerging evidence suggests that the bacterial symbiont plays a role in modulating insecticide resistance in insect. However, whether galectins influence insecticide susceptibility through microbiota regulation remains unclear.
View Article and Find Full Text PDFPestic Biochem Physiol
November 2025
College of Resources and Environment, Northeast Agricultural University, Harbin 150030, Heilongjiang, PR China. Electronic address:
Fomesafen (FSA), a diphenyl ether herbicide, causes toxicity to non-target organisms and subsequent crops. Vermi-remediation is advocated as an effective remediation method, but there has been no research on the isolation and mechanism of FSA-degradation strains from earthworm gut. In this study, three ecotypes of earthworms- Eisenia foetida (epigeic), Metaphire guillelmi (anecic), and Aporrectodea caliginosa (endogenic), were used to investigate the degradation mechanism of FSA in soil-plant-earthworm systems for the first time.
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