Cell polarity: centrosomes release signals for polarization.

Curr Biol

Graduate School of Life Sciences, Tohoku University, Sendai, 980-8577, Japan.

Published: April 2012


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

New findings reveal that, in Caenorhabditis elegans embryos, the centrosome provides signals that induce cell polarization, independently of its function as the microtubule-organizing center.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cub.2012.03.009DOI Listing

Publication Analysis

Top Keywords

cell polarity
4
polarity centrosomes
4
centrosomes release
4
release signals
4
signals polarization
4
polarization findings
4
findings reveal
4
reveal caenorhabditis
4
caenorhabditis elegans
4
elegans embryos
4

Similar Publications

How compartments talk: Compartment coupling guides cochlear development.

PLoS Biol

September 2025

Otolaryngology-Head & Neck Surgery, Stanford University School of Medicine, Stanford, California, United States of America.

Morphogens cooperate to guide development of the inner ear cochlea, but how do compartments communicate? A recent study in PLOS Biology reveals how planar cell polarity of individual cells is integrated across distinct regional compartments to ensure proper organ morphogenesis.

View Article and Find Full Text PDF

Biosensors for Detecting Small Rho GTPases: Monitoring Expression and Activation.

Bioessays

September 2025

MY Small G Protein Research Group, Bioprocess Technology Division, School of Industrial Technology, Universiti Sains Malaysia, Pulau Pinang, Malaysia.

Advanced biosensing technologies, such as Förster resonance energy transfer (FRET) and bioluminescence resonance energy transfer (BRET), have enabled real-time, high-resolution tracking of Rho GTPase activity, surpassing traditional methods like pull-down assays. However, current biosensors mainly detect the GTP-bound active state through effector interactions, without directly measuring Rho GTPase expression or identifying related biomarkers of abnormal activation. Small Rho GTPases are essential molecular switches that regulate key cellular processes such as cytoskeletal organization, cell movement, polarity, vesicle trafficking, and the cell cycle.

View Article and Find Full Text PDF

Morphogenetic information arises from a combination of genetically encoded cellular properties and emergent cellular behaviors. The spatio-temporal implementation of this information is critical to ensure robust, reproducible tissue shapes, yet the principles underlying its organization remain unknown. We investigated this principle using the mouse auditory epithelium, the organ of Corti (OC).

View Article and Find Full Text PDF

Background: Genetic modifiers are believed to play an important role in the onset and severity of polycystic kidney disease (PKD), but identifying these modifiers has been challenging due to the lack of effective methodologies.

Methods: We generated zebrafish mutants of IFT140, a skeletal ciliopathy gene and newly identified autosomal dominant PKD (ADPKD) gene, to examine skeletal development and kidney cyst formation in larval and juvenile mutants. Additionally, we utilized ift140 crispants, generated through efficient microhomology-mediated end joining (MMEJ)-based genome editing, to compare phenotypes with mutants and conduct a pilot genetic modifier screen.

View Article and Find Full Text PDF

Exosomes derived from various cells have been demonstrated to contribute to cardiac repair by regulating macrophage polarization in myocardial infarction. However, how exosomes secreted from cardiomyocytes under hypoxia-ischemia (Hypo-Exo) regulate macrophage polarization in the local tissues is elusive. This study aimed to determine the underlying mechanisms by which Hypo-Exo polarized M2 macrophages.

View Article and Find Full Text PDF