Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The efficiency of synaptic transmission undergoes plastic modification in response to changes in input activity. This phenomenon is most commonly referred to as synaptic plasticity and can involve different cellular mechanisms over time. In the short term, typically in the order of minutes to 1 h, synaptic plasticity is mediated by the actions of locally existing proteins. In the longer term, the synthesis of new proteins from existing or newly synthesized mRNAs is required to maintain the changes in synaptic transmission. Many studies have attempted to identify genes induced by neuronal activity and to elucidate the functions of the encoded proteins. In this chapter, we describe our current understanding of how activity can regulate the synthesis of new proteins, how the distribution of the newly synthesized protein is regulated in relation to the synapses undergoing plasticity and the function of these proteins in both Hebbian and homeostatic synaptic plasticity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/978-3-7091-0932-8_15 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Treg Cells Modulate Neuroinflammation and Behavioral Deficits in Autism: Evidence From MR-Based Genetic Analyses and Experimental Models.
Am J Med Genet B Neuropsychiatr Genet
September 2025
The Central Lab, the Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People's Republic of China.
Autism spectrum disorder (ASD) is a neurodevelopmental condition that is increasingly linked to immune dysfunction and neuroinflammation. Regulatory T cells (Tregs), which are crucial in maintaining immune homeostasis, have been implicated in the pathogenesis of ASD. However, their role in neuroimmune interactions and behavioral outcomes remains poorly understood.
View Article and Find Full Text PDFBOLD Long-Range Temporal Correlations Reflect Changes in Language and Depression Across Intensive Aphasia Therapy.
Stroke
September 2025
Brain Language Laboratory, Freie Universität Berlin, Germany (A.-T.P.J., M.R.O., A.S., F.P.).
Background: Intensive language-action therapy treats language deficits and depressive symptoms in chronic poststroke aphasia, yet the underlying neural mechanisms remain underexplored. Long-range temporal correlations (LRTCs) in blood oxygenation level-dependent signals indicate persistence in brain activity patterns and may relate to learning and levels of depression. This observational study investigates blood oxygenation level-dependent LRTC changes alongside therapy-induced language and mood improvements in perisylvian and domain-general brain areas.
View Article and Find Full Text PDFSpike-timing-dependent plasticity offers delay-gated oscillatory potentiation for autaptic weights.
Front Neural Circuits
September 2025
Faculty of Science and Engineering, Waseda University, Shinjuku, Tokyo, Japan.
Neuronal networks in animal brains are considered to realize specific filter functions through the precise configuration of synaptic weights, which are autonomously regulated without external supervision. In this study, we employ a single Hodgkin-Huxley-type neuron with autapses as a minimum model to computationally investigate how spike-timing-dependent plasticity (STDP) adjusts synaptic weights through recurrent feedback. The results show that the weights undergo oscillatory potentiation or depression with respect to autaptic delay and high-frequency stimulation.
View Article and Find Full Text PDFHow perceptual learning rewires brain connectivity: lessons from the visual system in a top-down perspective.
Front Neural Circuits
September 2025
Neuroscience Institute, National Research Council (CNR), Pisa, Italy.
Neural circuits sculpt their structure and modify the strength of their connections to effectively adapt to the external stimuli throughout life. In response to practice and experience, the brain learns to distinguish previously undetectable stimulus features recurring in the external environment. The unconscious acquisition of improved perceptual abilities falls into a form of implicit learning known as perceptual learning.
View Article and Find Full Text PDFDeviance detection and regularity sensitivity in dissociated neuronal cultures.
Front Neural Circuits
September 2025
Department of Mechano-Informatics, Graduate School of Information Science and Technology, The University of Tokyo, Tokyo, Japan.
Introduction: Understanding how neural networks process complex patterns of information is crucial for advancing both neuroscience and artificial intelligence. To investigate fundamental principles of neural computation, we examined whether dissociated neuronal cultures, one of the most primitive living neural networks, exhibit regularity sensitivity beyond mere stimulus-specific adaptation and deviance detection.
Methods: We recorded activity to oddball electrical stimulation paradigms from dissociated rat cortical neurons cultured on high-resolution CMOS microelectrode arrays.