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In November 2010, NDM-1-producing Klebsiella pneumoniae (NDMKP) was identified for the first time in South Korea from four patients with no history of traveling abroad who stayed for 21 to 205 days in a tertiary care hospital. All were sequence type (ST) 340 and had nearly identical XbaI pulsed-field gel electrophoresis (PFGE) patterns. The bla(NDM-1)-carrying plasmids were in the IncN group, with sizes ranging from 50 to 200 kb. These findings suggest that NDMKP had already been introduced into South Korea before this clustering was found.
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http://dx.doi.org/10.1128/JCM.06855-11 | DOI Listing |
J Glob Antimicrob Resist
June 2025
Catholic Research Institute for Human Genome Polymorphism, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Department of Internal Medicine, Division of Infectious Diseases, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Objective: Prolonged detection of multispecies New Delhi metallo-β-lactamase (NDM)-1-producing Enterobacterales was observed in front of a South Korean hospital. This study aimed to investigate the transmission mechanisms of bla and assess the role of environmental reservoirs in its persistence.
Methods: Epidemiological data were collected, and antibiotic susceptibility testing, carbapenemases detection, and whole-genome sequencing were performed on 42 clinical and 13 environmental isolates collected between November 2018 and February 2021, during the pre-outbreak, outbreak (July-September 2019), and post-outbreak periods.
J Trop Med
April 2025
Department of Pathobiology, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
Currently, carbapenem-resistant (CR-KP) strains, particularly those producing New Delhi metallo-beta-lactamase (NDM), are increasingly recognized as a significant threat to global health. The present study aimed to conduct a genomic analysis of an NDM-1-producing CR-KP strain isolated from patients with coronavirus disease of 2019 (COVID-19) admitted to the intensive care unit (ICU). The isolate was obtained from the bronchoalveolar lavage fluid of a 68 year-old male patient hospitalized in the ICU with COVID-19 at Besat Hospital in Sanandaj, Iran.
View Article and Find Full Text PDFJ Glob Antimicrob Resist
June 2025
Laboratory of Research on Clinical Microbiology (LPMC), School of Pharmacy, Federal University of Bahia, Ondina, Salvador, Bahia, Brazil; Laboratory of Pathology and Molecular Biology (LPBM), Gonçalo Moniz Research Institute, Oswaldo Cruz Foundation, Candeal, Salvador, Bahia, Brazil. Electronic add
Front Cell Infect Microbiol
April 2025
Department of Urology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, China.
Objectives: This study aimed to characterize the genomes of two rare ST592 isolates and to explore their evolution into carbapenem-resistant hypervirulent (CR-hvKp).
Methods: The minimum inhibitory concentrations (MICs) were determined using a VITEK 2 compact system. Conjugation experiments were conducted using film matings.
Antimicrob Agents Chemother
May 2025
Venatorx Pharmaceuticals Inc., Malvern, Pennsylvania, USA.
We determined the frequency of resistance to cefepime-taniborbactam in NDM-1-producing at <10. Isolated mutants that were less susceptible to cefepime-taniborbactam had an increased copy number of the gene or disruption of major porins OmpK36 and OmpK35. Antibacterial susceptibility testing using isogenic strains indicated that while cefepime penetrates into the periplasm mainly through the major porins, taniborbactam does not have a strong dependence on OmpK35 or OmpK36 for periplasmic accumulation.
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