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Pemphigus vulgaris is an autoimmune blistering disease that commonly involves the scalp. Lesions of pemphigus vulgaris that persist on the scalp for a long period may be accompanied by tufted hair folliculitis. Only two previous accounts of tufted hair folliculitis developing in a lesion of pemphigus vulgaris have been reported. We report a 51-year-old-man with erosions and clusters of hair on the scalp. The scalp lesion had persisted for about 20 years. A histopathological examination of the skin lesion on the scalp revealed separation of the epidermis and clusters of several adjacent hair follicles. The patient was diagnosed with persistent pemphigus vulgaris of the scalp showing features of tufted hair folliculitis.
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http://dx.doi.org/10.5021/ad.2011.23.4.523 | DOI Listing |
J Invest Dermatol
September 2025
Department of Dermatology and Allergology, Philipps University Marburg, Marburg, Germany. Electronic address:
Pemphigus vulgaris (PV) is an autoimmune blistering disorder, which is caused by the loss of desmosomal cell-cell adhesion, initiated by the binding of IgG antibodies against the desmosomal components desmoglein (Dsg)1 and Dsg3. Dsg3-reactive CD4 T helper (Th) cells, in particular follicular Th (Tfh) cells, play a central role in autoantibody production by Dsg3-specific B cells. In this study, we challenged the concept that distinct Dsg3-reactive CD4 T cell subsets are critical in PV pathogenesis utilizing phenotypical and functional state-of-the-art ex vivo assays.
View Article and Find Full Text PDFMinerva Dent Oral Sci
September 2025
Division of Dermatology Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna Italy.
Background: Enzyme-linked immunosorbent assay (ELISA) kits for BP180-NC16A use different cutoff levels established for cutaneous bullous pemphigoid (BP). However, in oral mucous membrane pemphigoid (OMMP), circulating antibodies are reported to be less readily detectable than cutaneous BP and there is little evidence that these cut-off levels are suitable for OMMP. This study was performed to explore whether the available cutoff values of anti-BP180-NC16A ELISA used for cutaneous BP are equally effective when applied to OMMP or should benefit from an optimized cut-off value.
View Article and Find Full Text PDFIndian J Dermatol
September 2025
From the Department of Dermatology, Venereology and Leprosy, GMC, Kota, Rajasthan, India.
Eczema Herpeticum (EH) or Kaposi's Varicelliform eruption (KVE) is a severe viral infection that occurs when herpes simplex virus infects an inflamed skin, most often occurring in patients with atopic dermatitis (AD) or other inflammatory skin conditions. To discern various primary dermatoses in which KVE occurred and to study the clinical features, course, and response to specific antiviral treatment along with a course of the primary dermatoses during the episode of KVE. Data was collected in the Dermatology Out-patient department of a tertiary care center in Northern India from December 2017 to March 2024, and it was tabulated and analysed.
View Article and Find Full Text PDFJ Dermatol
September 2025
Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan.
A 49-year-old man with pemphigus vegetans (PVeg) relapsed several times due to cessation of therapy. At the age of 66, vegetative plaques developed at the left oral commissure following mechanical plucking of approximately 500 beard hairs. Treatment with prednisolone (20 mg/day) was continued but yielded no clinical improvement.
View Article and Find Full Text PDFJ Am Acad Dermatol
September 2025
Department of Dermatology, Christian Medical College, Vellore, India. Electronic address: