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Intracardiac metastases of thyroid carcinoma are a rare event. Their incidence is low in large autopsy series, and antemortem diagnosis is even less common. We present the case of a woman with advanced poorly differentiated thyroid carcinoma who had extensive intracardiac metastases. This case highlights the usefulness of echocardiography and magnetic resonance imaging in the diagnosis and differential diagnosis of cardiac metastases.
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http://dx.doi.org/10.1111/j.1540-8175.2011.01549.x | DOI Listing |
Eur J Med Res
September 2025
Department of Zoology, Faculty of Science, Ain Shams University, Abbassia, Cairo, 11566, Egypt.
Nuclear receptors (NRs) are a superfamily of ligand-activated transcription factors that regulate gene expression in response to metabolic, hormonal, and environmental signals. These receptors play a critical role in metabolic homeostasis, inflammation, immune function, and disease pathogenesis, positioning them as key therapeutic targets. This review explores the mechanistic roles of NRs such as PPARs, FXR, LXR, and thyroid hormone receptors (THRs) in regulating lipid and glucose metabolism, energy expenditure, cardiovascular health, and neurodegeneration.
View Article and Find Full Text PDFBMC Endocr Disord
September 2025
Internal Medicine Department, Faculty of Medicine, Beni-Suef University, Beni-Suef City, 62514, Egypt.
Background: Thyroid nodules (TNs) are frequent and often benign. Accurately differentiating between benign and malignant nodules is crucial for proper management. This research aims to use ultrasonography to examine TNs and identify possible risk factors in order to improve patient outcomes and diagnostic accuracy.
View Article and Find Full Text PDFCell Death Dis
September 2025
Department of Endocrinology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, China.
In recent years, there has been a rapid increase in the incidence of thyroid carcinoma (TC). Our study focuses on the regulatory effect of circular RNAs on metabolism of TC, aiming to provide new insights into the mechanisms of progression and a potential therapeutic target for TC. In this study, we identified high expression levels of circPSD3 in TC tissues through RNA sequencing.
View Article and Find Full Text PDFVirchows Arch
September 2025
Ningbo Clinical Pathology Diagnosis Center, #685 Huancheng North Road, Ningbo, Zhejiang, 315000, China.
The spindle cell variant of papillary thyroid carcinoma (PTC) is exceptionally rare and poses significant diagnostic challenges due to its morphological overlap with other spindle cell lesions of the thyroid. We report a novel case of spindle cell variant PTC in a 66-year-old woman presenting with a TI-RADS 4 thyroid nodule, initially classified as Bethesda III on fine-needle aspiration. Histopathological examination revealed a biphasic tumor composed predominantly of bland spindle cells arranged in solid sheets and fascicles, admixed with entrapped thyroid follicles.
View Article and Find Full Text PDFCureus
August 2025
Faculty of Medicine, University of Costa Rica, San José, CRI.
Struma ovarii (SO) is a rare form of ovarian teratoma predominantly composed of thyroid tissue. While most cases follow a benign course, some may exhibit malignant transformation or extra-ovarian spread. We present the case of a 43-year-old woman with a history of SO previously treated with right oophorectomy and systemic chemotherapy, along with a separate diagnosis of papillary thyroid carcinoma managed with total thyroidectomy and radioactive iodine ablation.
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