A new approach to prepare well-dispersed CaF(2) nanoparticles by spray drying technique.

Previously, nano-sized calcium fluoride (CaF₂) particles were prepared using a spray drying method by simultaneously feeding Ca(OH)₂ and NH₄F solutions to a two-liquid nozzle. The aim of the present study was to prepare better-dispersed nano-CaF₂ particles by co-forming a soluble salt, sodium chloride (NaCl). NaCl of various concentrations were added to the NH(4) F solution, leading to formation of (CaF₂ +NaCl) composites with CaF₂ /NaCl molar ratios of 4/1, 4/4, and 4/16. Pure nano-CaF₂ was also prepared as the control. Powder X-ray diffraction analysis showed that the products contained crystalline CaF₂ and NaCl. Scanning electron microscopy examinations showed that both the CaF₂ /NaCl composite and pure CaF₂ particles were about (50-800) nm in size and consisted of primary CaF₂ particles of < 50 nm in size. BET surface area measurements showed similar primary particle sizes for all samples. Dynamic light scattering measurements showed that the washed (CaF₂+NaCl) particles were much smaller than the pure CaF₂ as the dissolution of NaCl "freed" most of the primary CaF₂ particles, leading to a greater degree of particle dispersion. The well-dispersed nano-CaF₂ may be expected to be a more effective anticaries agent than NaF by providing longer lasting elevations of fluoride concentrations in oral fluids.