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In allometry, bivariate techniques related to principal component analysis are often used in place of linear regression, and primary interest is in making inferences about the slope. We demonstrate that the current inferential methods are not robust to bivariate contamination, and consider four robust alternatives to the current methods -- a novel sandwich estimator approach, using robust covariance matrices derived via an influence function approach, Huber's M-estimator and the fast-and-robust bootstrap. Simulations demonstrate that Huber's M-estimators are highly efficient and robust against bivariate contamination, and when combined with the fast-and-robust bootstrap, we can make accurate inferences even from small samples.
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http://dx.doi.org/10.1002/bimj.201000018 | DOI Listing |
JAACAP Open
September 2025
Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York.
Objective: The bidirectional relationships between family functioning and adolescent depressive and anxiety disorders have been documented. However, categorical diagnostic criteria for these disorders often mask the high variability of symptom severity across individuals sharing the same diagnoses. Accounting for such heterogeneity, this study examined the associations between domains of family functioning and depression, anxiety, and anhedonia symptoms from the adolescent perspective using a dimensional approach.
View Article and Find Full Text PDFHGG Adv
September 2025
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA; Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA. Electronic address:
Pleiotropy, the phenomenon where a genetic region confers risk to multiple traits, is widely observed, even among seemingly unrelated traits. Knowledge of pleiotropy can improve understanding of biological mechanisms of diseases/traits, and can potentially guide identification of molecular targets or help predict side-effects in drug development. However, statistical approaches for identifying pleiotropy genome-wide are limited, particularly for two correlated traits or case-control traits with unknown sample overlap or for disease traits from family studies.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Cardiology, Yale New Haven Health System, Yale New Haven Hospital, New Haven, Connecticut, United States of America.
Background: Heart failure (HF) mortality is rising despite robust evidence-based guidelines. Hospitalization presents an opportune time to optimize care. Inpatient care pathways (CP) embedded in the electronic health record (EHR) can enhance adherence to guidelines by providing real-time decision support.
View Article and Find Full Text PDFJ Med Internet Res
August 2025
Department of Radiology, The First Hospital of Jilin University, 71 Xinxin Street, Chaoyang District, Changchun City, Jilin Province, China, Jilin, CN.
Background: Despite AI models demonstrating high predictive accuracy for early cholangiocarcinoma(CCA) recurrence, their clinical application faces challenges such as reproducibility, generalizability, hidden biases, and uncertain performance across diverse datasets and populations, raising concerns about their practical applicability.
Objective: This meta-analysis aims to systematically assess the diagnostic performance of artificial intelligence (AI) models utilizing computed tomography (CT) imaging to predict early recurrence of CCA.
Methods: A systematic search was conducted in PubMed, Embase, and Web of Science for studies published up to May 2025.
JMIR Med Inform
September 2025
Department of Epidemiology and Public Health, Institue of Epidemiology and Health Care, University College London, 1-19 Torrington Place, London, United Kingdom, 44 207679200.
Background: The primary health care service in Indonesia consists of 10,260 public health centers (Puskesmas), which play a major role in providing health care in the community, recording and reporting health data using digital health information systems (HIS) or manual reports. The utilization of HIS across Puskesmas is crucial to capture the dynamic evolution of health problems and monitor interventions, thus providing effective primary health care services for the community.
Objective: This paper provides a national-level baseline mapping of HIS utilization in Indonesian Puskesmas.