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Background And Importance: Status epilepticus (SE) refractory to medical treatment has a high mortality rate and few effective treatments.
Clinical Presentation: We describe the implantation of a vagal nerve stimulator to help terminate a case of refractory SE. A 23-year-old man was in SE for 3 weeks without being able to be weaned from intravenous anesthetic agents. After implantation of a vagal nerve stimulator, SE soon terminated, and the patient could be weaned from sedative agents and made a full recovery.
Conclusion: Vagal nerve stimulator should be considered in cases of refractory SE.
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http://dx.doi.org/10.1227/NEU.0b013e318223b979 | DOI Listing |
Neurol Sci
September 2025
Pediatric Neurosurgery Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Background: super-refractory status epilepticus (SRSE) is a rare and severe neurological condition associated with high mortality and significant long-term morbidity. In many cases, conventional medical treatments prove ineffective, with wide use of off-label therapies.
Methods: two researchers conducted a review of the medical records of subjects who had undergone VNS implantation in our tertiary Centre.
Epileptic Disord
September 2025
APHM, Timone Hospital, Epileptology and Cerebral Rhythmology, Marseille, France.
This case study reports the first documented use of stereoelectroencephalography (SEEG)-guided radiofrequency thermocoagulation (RFTC) to treat refractory status epilepticus (RSE). A 33-year-old woman with drug-resistant epilepsy and recurrent RSE underwent SEEG to define her epileptogenic zone. A new RSE started shortly before and continued during the SEEG exploration, being unresponsive to multiple antiseizure medications, vagal nerve stimulation, and corticosteroid therapy.
View Article and Find Full Text PDFJTCVS Open
August 2025
Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine and the University of Pittsburgh Medical Center, Pittsburgh, Pa.
Objectives: Laparoscopic repair of giant paraesophageal hernia (LGPEHR) is a complex operation and typically includes an antireflux procedure (ARS); however, some patients without a history of reflux may be able to avoid an ARS. The objective of this study was to evaluate an alternative approach for giant paraesophageal hernia (GPEH) repair with restoration of the normal anatomy and an extended gastropexy in selected patients with minimal reflux symptoms.
Methods: Patients who underwent GPEH repair with an extended gastropexy were reviewed retrospectively.
PLoS One
September 2025
Faculty of Psychology, Mental Health Research and Treatment Center, Ruhr University Bochum, Bochum, Germany.
Background: Eating disorders such as Anorexia Nervosa (AN) and Bulimia Nervosa (BN) were previously found to partly entail alterations in stress physiology including salivary cortisol (sC), and salivary alpha amylase (sAA) at rest and basal vagal tone (HF-HRV), compared to individuals without mental disorders or with mixed mental disorders (anxiety and depressive disorders), but corresponding data remain scarce and are not entirely consistent.
Method: HF-HRV, sC and sAA at rest were assessed in a female sample of 58 individuals with AN and 54 individuals with BN before and after psychotherapy and contrasted against measurements from 59 female individuals suffering from mixed disorders and 101female healthy controls.
Results: Values for sC were elevated in AN compared to all other groups, those for HF-HRV were highest in both AN and BN and lowest in mixed mental disorders and no differences were found at rest for sAA.
Heart Rhythm O2
August 2025
Division of Cardiology, Arrhythmia Section, Zentralklinik Bad Berka, Germany.
Background: Damage to peri-esophageal tissue may occur following pulmonary vein isolation (PVI). Active esophageal cooling has been shown to reduce the incidence of mucosal esophageal injury, probably by dissipation of heat and inhibition of inflammation. Whether it also protects the peri-esophageal vagal nerve plexus and reduces gastric hypomotility and food retention is uncertain.
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