Choline dendrimers as generic scaffolds for the non-covalent synthesis of multivalent protein assemblies.

Chem Commun (Camb)

Instituto de Biología Molecular y Celular, Universidad Miguel Hernández, Avda Universidad s/n, Elche 03202, Spain.

Published: June 2011


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Article Abstract

A modular self-assembly strategy is presented that allows the non-covalent synthesis of multivalent protein dendrimers using the strong interaction between choline-functionalized dendrimers and the choline binding protein C-LytA. Choline dendrimers displaying fusion proteins of C-LytA and the collagen binding protein CNA35 represent attractive multivalent targeting ligands for collagen imaging.

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http://dx.doi.org/10.1039/c0cc05605gDOI Listing

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