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Crosstalk between leukemic cells and their surrounding mesenchymal stromal cells (MSCs) in the bone marrow microenvironment is crucial for the pathogenesis of myelodysplastic syndromes (MDS) and is mediated by extracellular vesicles (EVs). The EV-specific miRNAs derived from MDS-MSCs remain poorly explored. EVs isolated from HS-5, an immortalized stromal cell line, promoted the proliferation and 5-azacytidine (AZA) resistance of SKM-1 cells.
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View Article and Find Full Text PDFPiezo1 promotes M1 macrophage polarization and impairs osteogenic differentiation in bone infection.
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Department of Orthopaedics, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, No.466 Xingang Road, Haizhu District, Guangzhou, 510317, PR China; Southern Medical University, No. 1023-1063, Satai South Road, Baiyun District, Guangzhou, 510515, PR China. Electronic addre
Background: Bone infection induces a strong inflammatory response and leads to impaired bone regeneration, in which macrophages sense mechanistic signals and modulate immune responses in the inflammatory microenvironment through Piezo1. Nonetheless, the regulatory role of Piezo1 in macrophages during bone infection remains elusive.
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The use of injectable orthobiologics for knee osteoarthritis: A formal ESSKA-ORBIT consensus. Part 2-Cell-based therapy.
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