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Congenital and acquired neutropenia are rare disorders whose frequency in pediatric age may be underestimated due to remarkable differences in definition or misdiagnosed because of the lack of common practice guidelines. Neutropenia Committee of the Marrow Failure Syndrome Group (MFSG) of the AIEOP (Associazione Italiana Emato-Oncologia Pediatrica) elaborated this document following design and methodology formerly approved by the AIEOP board. The panel of experts reviewed the literature on the topic and participated in a conference producing a document which includes a classification of neutropenia and a comprehensive guideline on diagnosis of neutropenia.
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http://dx.doi.org/10.1002/pbc.23108 | DOI Listing |
Circ Genom Precis Med
September 2025
Clinical Pharmacology and Precision Medicine, William Harvey Research Institute, London, United Kingdom (W.J.Y., M.M.S., J.R., S.v.D., H.R.W., A.T., P.B.M.).
Background: There is a higher prevalence of heart rate corrected QT (QTc) prolongation in patients with diabetes and metabolic syndrome. QT interval genome-wide association studies have identified candidate genes for cardiac energy metabolism, and experimental studies suggest that polyunsaturated fatty acids have direct effects on ion channel function. Despite this, there has been limited study of metabolite concentration relationships with QT intervals.
View Article and Find Full Text PDFPediatr Cardiol
September 2025
Division of Cardiology, Children's National Hospital, 111 Michigan Ave, Washington, DC, 20010, USA.
Patients with acquired and congenital heart disease (CHD) are at higher risk of hospitalization. Despite quality improvement (QI) initiatives, many patients experience readmission soon after discharge. We aimed to identify risk factors for 30-day readmission and hypothesized that direct discharge from the cardiac intensive care unit (CICU) is associated with an increased readmission rate.
View Article and Find Full Text PDFIntern Med
September 2025
Department of Hematology and Oncology, University of Fukui Hospital, Japan.
Symptoms of bleeding caused by vitamin K-dependent coagulation factor deficiency (VKCFD) are rare in adults. We present two Japanese cases of adult-onset VKCFD, in which the cause of vitamin K deficiency remains unknown despite comprehensive evaluation. Both patients showed markedly decreased levels of coagulation factors (F) VII, FIX, FX, FII, protein C (PC), and protein S (PS), along with elevated levels of protein induced by vitamin K absence/antagonist II (PIVKA-II).
View Article and Find Full Text PDFWorld J Pediatr Congenit Heart Surg
September 2025
Postgraduate Program in Health Sciences, Medical School, Federal University of Amazonas (UFAM), Manaus, Amazonas, Brazil.
To analyze in-hospital mortality in children undergoing congenital heart interventions in the only public referral center in Amazonas, North Brazil, between 2014 and 2022. This retrospective cohort study included 1041 patients undergoing cardiac interventions for congenital heart disease, of whom 135 died during hospitalization. Records were reviewed to obtain demographic, clinical, and surgical data.
View Article and Find Full Text PDFCureus
August 2025
Cardiology, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Rabat, MAR.
Subaortic membrane (SAM) is a subtype of left ventricular outflow obstruction, rarely seen in adults. In some cases, SAM may be associated with other congenital defects. The association of patent ductus arteriosus (PDA) and SAM is the rarest, especially in adult patients.
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