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http://dx.doi.org/10.1111/j.1365-2141.2010.08484.x | DOI Listing |
Cancer Sci
September 2025
Department of Surgery, Asahikawa Medical University, Asahikawa, Japan.
Despite recent advances in neoadjuvant strategies for locally advanced rectal cancer (LARC), optimal chemotherapy regimens and the role of genetic biomarkers in guiding treatment remain unclear. Moreover, predictive markers are urgently needed for radiation-sparing strategies. Therefore, we aimed to assess the predictive and prognostic value of TP53, KRAS, and APC mutations in patients with LARC undergoing neoadjuvant chemotherapy (NACT) by retrospectively analyzing 43 patients with LARC who underwent NACT without radiation.
View Article and Find Full Text PDFClin Exp Dent Res
October 2025
Faculty of Medicine, Department of Clinical Biochemistry, Mazandaran University of Medical Sciences, Sari, Iran.
Objectives: Oral lichen planus (OLP) is a chronic inflammatory disorder of the oral mucosa, genetic and molecular alterations, including mutations in the p53 tumor suppressor gene, have been implicated in OLP pathogenesis. However, its molecular mechanisms are not clearly understood. This study investigates p53 gene mutations in OLP lesions.
View Article and Find Full Text PDFPathol Res Pract
September 2025
Department of Pathology, Peking University People's Hospital, Beijing 100044, China. Electronic address:
Background: Mesonephric-like adenocarcinoma (MLA) is a rare gynecological malignancy,during diagnosis, it is frequently mistaken for other gynecological malignancies because different development patterns coexist under a microscope. This study aims to provide a more comprehensive understanding of the disease by analyzing the clinical and pathological characteristics, immunohistochemistry, and molecular features of MLA.
Methods: A retrospective analysis was conducted on 17 patients with mesonephric-like adenocarcinomadiagnosed by the Department of Pathology at Peking University People's Hospital from January 2021 to June 2025.
Asian Pac J Cancer Prev
July 2025
Goswami Ganesh Dutta Sanatan Dharma College, Palwal, India.
Background: Polymorphism of P53 gene has been explored worldwide to know the genetic predisposition of ovarian cancer, however.literature reports inconsistent association between codon 72 polymorphism and ovarian cancer risk.Several studies have reported a higher incidence of ovarian cancer associated with the Pro variant, while others found non-significant association.
View Article and Find Full Text PDFBr J Cancer
July 2025
Department of Medical Biosciences, Umea University, Umea, Sweden.
Background: Synonymous mutations (SMs) change the mRNA nucleotide sequences without altering the corresponding amino acid sequence and are usually overlooked due to their perceived lack of influence on protein function. However, emerging reports suggest that SMs play a significant role in disease development and progression.
Methods: Whole exome sequencing, RNA-sequencing, and droplet digital PCR were performed to identify the SMs from the malignant glioma patients.