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We designed a weighted cross-correlation coefficient considering the "anchor" of the T cell epitopes, and used an evolutionary algorithm to search for an optimal weight vector. A SVM model with this new peptide similarity kernel was evaluated on a T-cell data set. The results demonstrated a good performance of this method.
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bioRxiv
August 2025
Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
Physiological brain pulsations, primarily driven by cardiac and respiratory activity, play a key role in driving neurofluid circulation and waste clearance. Capturing the temporal dynamics of cardiac- and respiratory-driven brain pulsations (0.2-1.
View Article and Find Full Text PDFJ Acoust Soc Am
July 2025
Department of Computer Science and Engineering, The Ohio State University, Columbus, Ohio 43210, USA.
In the presence of room reverberation and background noise, the performance of frame-level speaker localization is severely limited. To address this challenge, this study performs multi-channel speech enhancement based on complex spectral mapping (CSM), followed by direction-of-arrival (DOA) estimation using weighted generalized cross-correlation with phase transform (GCC-PHAT). The proposed approach differs from prevailing deep learning methods that operate on multi-channel inputs directly for speaker localization.
View Article and Find Full Text PDFUltrasonics
December 2025
Institute of Electronics, National Yang Ming Chiao Tung University, Taiwan. Electronic address:
Flow trajectory imaging, which tracks flow particles over time to map path-dependent trajectories, is a valuable tool for analyzing flow dynamics in pathological vascular conditions. Accurate trajectory estimation depends on robust vector flow imaging (VFI) methods to minimize cumulative errors. However, Doppler-based VFI methods are limited by aliasing and ensemble-sensitive estimation errors, while speckle tracking (ST) methods suffer from poor lateral velocity estimation due to beam diffraction.
View Article and Find Full Text PDFSensors (Basel)
June 2025
State Grid Tianjin Electric Power Research Institute, Tianjin 300180, China.
Partial discharge (PD) in insulators will not only lead to the gradual degradation of insulation performance but even cause power system failure in serious cases. Because there is strong noise interference in the field, it is difficult to accurately locate the position of the PD source. Therefore, this paper proposes a three-dimensional spatial localization method of the PD source with a four-element ultra-high-frequency (UHF) array based on improved wavelet packet dynamic threshold denoising and the Gxx-β generalized cross-correlation algorithm.
View Article and Find Full Text PDFJ Phys Chem B
September 2025
Department of Chemistry and Chemical Biology, Indian Institute of Technology (ISM) Dhanbad, Dhanbad 826004, India.
Parkinson's disease (PD) is a complex neurological disorder driven by the dysfunction of key protein components. In this regard, 14-3-3η, a ubiquitous protein-protein interaction (PPI) facilitator, complexes with Parkin, an E3 ligase, inactivating the latter. This interaction promotes oxidative stress in dysfunctional mitochondria, ultimately causing neuronal cell death.
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