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http://dx.doi.org/10.1016/j.maturitas.2010.08.009 | DOI Listing |
Curr Treat Options Oncol
September 2025
Division of Gynecologic Oncology, Department of Surgery, City of Hope National Medical Center, Duarte, CA, USA.
Ovarian cancer, particularly high-grade serous carcinoma (HGSC), remains a leading cause of mortality in gynecologic oncology. Emerging research identifies serous tubal intraepithelial carcinoma (STIC) as a precursor lesion in many HGSC cases, highlighting its role in ovarian cancer pathogenesis and prevention. Management of STIC is challenging, as there is only limited data available to guide clinical decision-making.
View Article and Find Full Text PDFACS Omega
August 2025
Office of Research Administrations, Chiang Mai University, Chiang Mai 50200, Thailand.
The early 1990s marked a pivotal era in oncology with the elucidation of the molecular etiology of hereditary cancers, fundamentally transforming our understanding of genetic susceptibility. Ovarian cancer (OC) remains the most fatal gynecologic malignancy, often diagnosed at advanced stages with limited modifiable risk factors. Globally, it ranks as the eighth most frequently diagnosed cancer in women, underscoring its significant public health burden.
View Article and Find Full Text PDFCureus
August 2025
Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JPN.
Introduction Risk-reducing salpingo-oophorectomy (RRSO) can substantially reduce ovarian cancer incidence in women carrying pathogenic or variants, which cause hereditary breast and ovarian cancer syndrome. The decision to undergo RRSO or continue surveillance is influenced by personal background and psychosocial factors, but the process in Japan has not been well studied. Even among women who ultimately choose RRSO, some proceed promptly, while others delay.
View Article and Find Full Text PDFEur J Obstet Gynecol Reprod Biol X
September 2025
Department of Obstetrics and Gynaecology, Zuyderland Medical Centre, Henri Dunantstraat 5, Heerlen 6419 PC, the Netherlands.
Objective: Vaginal natural orifice transluminal endoscopy (vNOTES) is a minimally invasive technique gaining popularity for several gynaecological procedures. This study presents the first 81 adnexal cases, performed in The Netherlands.
Design Setting Participants And Intervention: This retrospective cohort study included patients who underwent vNOTES adnexal surgery for benign indications at Zuyderland Medical Centre between March 2020 and August 2024.
Gynecol Oncol
August 2025
Program in Epidemiology, Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. Electronic address:
This article summarizes the key findings presented in the Prevention, Early Detection, & Interception Session at 15th Biennial Ovarian Cancer Research Symposium organized by the Rivkin Center for Ovarian Cancer and American Association for Cancer Research on September 20-21st in Seattle, Washington. The wide range of topics covered in this session included prevention, early detection, and its interception in basic science, clinical science, and population science. More specifically, risk-reducing salpingo-oophorectomy in women at high-risk of ovarian cancer, biology of early progression, mechanisms involved in the transition from precursor lesion to high grade serous ovarian cancer, population-based studies on prevention, and early detection biomarkers of ovarian cancer were discussed.
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