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A group A streptococcal (GAS) vaccine, while not currently available, offers the possibility of a more effective approach; however, barriers to its implementation are likely to exist. The objectives of this study were to describe the attitudes of physicians about the importance of preventing GAS-associated conditions and to identify potential barriers to vaccine implementation. Surveys were sent to randomly selected physicians from the AAP and the AAFP. The GAS conditions believed by respondents to be most important to prevent among pediatric patients were ARF (31%) followed by STSS (24%) and pharyngitis (20%). Pediatricians and family physicians identified similar factors that would encourage routine use of a GAS vaccine. Less than half of pediatricians and only a third of family physicians would recommend a GAS vaccine if it could not be given concurrently with other immunizations or if there were strong parental resistance to the vaccine. This descriptive study provides important information about the anticipated use of a GAS vaccine by primary care physicians in the United States.
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http://dx.doi.org/10.1016/j.vaccine.2010.08.071 | DOI Listing |
J Pharm Sci
September 2025
Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66047, USA; Biopharmaceutical Innovation and Optimization Center, University of Kansas, Lawrence, KS 66047, USA. Electronic address:
Solubility behavior is an important attribute to rank-order monoclonal and bispecific antibody (mAb, biAb) candidates during developability assessments. Current approaches to directly measure antibody solubility without adding precipitating additives (e.g.
View Article and Find Full Text PDFFront Pediatr
August 2025
Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, University of London, London, United Kingdom.
Emerging evidence suggests a potential link between maternal SARS-CoV-2 infection during early pregnancy and the development of congenital heart defects (CHD) in offspring. Although vertical transmission of SARS-CoV-2 is rare, the virus has been associated with placental complications and increased maternal morbidity. Recent studies from China report increased rates of CHD and anomalies such as situs inversus when infection occurs during gestational weeks 4-6, a critical window for cardiac development.
View Article and Find Full Text PDFFront Immunol
August 2025
The Pirbright Institute, Woking, United Kingdom.
Viruses
August 2025
School of Medicine, University of Louisville, 505 S. Hancock Street, Louisville, KY 40202, USA.
There is a need for safe and effective vaccines against the Venezuelan equine encephalitis virus that infects both humans and equines. However, development of a live-attenuated vaccine using the TC-83 strain has been hampered by substantial reactogenicity and the potential for neuroinvasion. In this study, we demonstrate that V4020, a new TC-83-based investigational VEEV vaccine with redundant safety features preventing neuroinvasion and reversion, exhibited no neuroinvasion potential in a murine model.
View Article and Find Full Text PDFMicroorganisms
August 2025
Università degli Studi di Milano, 20122 Milan, Italy.
(Group A , GAS) is a major human pathogen capable of causing infections ranging from mild pharyngitis and impetigo to severe invasive diseases such as bacteremia, necrotizing fasciitis, and streptococcal toxic shock syndrome (STSS). Historically, the incidence of GAS infections declined during the early antibiotic era but began rising again from the early 2000s, driven partly by the emergence of hyper-virulent strains such as and . From 2005 onward, significant increases in GAS infections were reported globally, accompanied by rising antibiotic resistance, particularly to macrolides and tetracyclines.
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