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Article Abstract
Objective: To study whether Notch signaling, which regulates cell fate decisions and vessel morphogenesis, controls lymphatic development.
Methods And Results: In zebrafish embryos, sprouts from the axial vein have lymphangiogenic potential because they give rise to the first lymphatics. Knockdown of delta-like-4 (Dll4) or its receptors Notch-1b or Notch-6 in zebrafish impaired lymphangiogenesis. Dll4/Notch silencing reduced the number of sprouts producing the string of parchordal lymphangioblasts; instead, sprouts connecting to the intersomitic vessels were formed. At a later phase, Notch silencing impaired navigation of lymphatic intersomitic vessels along their arterial templates.
Conclusions: These studies imply critical roles for Notch signaling in the formation and wiring of the lymphatic network.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497575 | PMC |
| http://dx.doi.org/10.1161/ATVBAHA.110.203034 | DOI Listing |
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