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It must have been network (percolation for the synaptic function). | LitMetric

It must have been network (percolation for the synaptic function).

Mol Cell

Laboratory of Molecular Neuroscience, German Center for Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany; Institute of Biochemistry, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, 10117 Berlin

Published: September 2025


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Article Abstract

How does synaptic wiring depend on receptor clustering, scaffold networks, and signaling cohorts? In a recent study in Molecular Cell, Jia et al. demonstrate that targeting the interaction strength between the scaffold proteins, rather than the total amount of each protein component, modulates the signal propagation across the protein network.

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http://dx.doi.org/10.1016/j.molcel.2025.08.013DOI Listing

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