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Purpose: To compare the effects of fluidic parameters on the central corneal thickness (CCT), corneal endothelium, and anterior segment inflammation after phacoemulsification with longitudinal ultrasound.
Setting: Iladevi Cataract & IOL Research Center, Ahmedabad, India.
Methods: In this prospective randomized patient- and examiner-masked study, consecutive patients with age-related cataract were randomly assigned to Group 1 (low fluidic parameters: aspiration flow rate 25 cc/min; bottle height 70 cm and 90 cm; vacuum
Results: The mean change in CCT from preoperatively to 1 day postoperatively was -6.49% +/- 2.7% in Group 1 and -13.44% +/- 4.3% in Group 2 and from preoperatively to 7 days, -1.74% +/- 1.3% microm and -5.55% +/- 4.3%, respectively (both P<.001). There was no statistically significant difference in the rate of change in ECD between groups from preoperatively to 3 months postoperatively (4.67% +/- 0.15% versus -5.22% +/- 2.84% (P = .45). Anterior chamber flare, cells, and corneal clarity at 1 day were significantly better in Group 1 than in Group 2.
Conclusion: Low fluidic parameters led to a lower increase in CCT 1 day and 7 days postoperatively, decreased anterior segment inflammation at 1 day, and yielded clear corneas.
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http://dx.doi.org/10.1016/j.jcrs.2009.11.009 | DOI Listing |
Micromachines (Basel)
July 2025
Research Center in Industrial Technologies CRTI, Cheraga, P.O. Box 64, Algiers 16014, Algeria.
The propagation of interface acoustic waves (IAWs) along rotated YX-LiNbO/SU-8/ZX-Si structures is theoretically investigated to identify the Y-rotation angles that support the efficient propagation of low-loss modes guided along the structure's interface. A three-dimensional finite element analysis was performed to simulate IAW propagation in the layered structure and to optimize design parameters, specifically the thicknesses of the platinum (Pt) interdigital transducers (IDTs) and the SU-8 adhesive layer. The simulations revealed the existence of two types of IAWs travelling at different velocities under specific Y-rotated cuts of the LiNbO half-space.
View Article and Find Full Text PDFAdv Sci (Weinh)
August 2025
Department of Biomedical Engineering, University of Rochester, Rochester, NY, 14627, USA.
The blood-brain barrier (BBB) maintains cerebral homeostasis and protects the central nervous system (CNS) during systemic inflammation. Advanced in vitro models integrating circulation, a functional BBB, and reactive glial cells are essential for studying the link between peripheral inflammation and neuroinflammation. Fluid shear stress, a key hemodynamic parameter, strengthens microvascular barriers.
View Article and Find Full Text PDFTransl Vis Sci Technol
August 2025
School of Engineering, Newcastle University, Newcastle upon Tyne, UK.
Purpose: The purpose of this study was to investigate the field of fluidic effect (FOE) at the vitrectomy port in a range of artificial vitreous solutions (AVS) with varying rheological characteristics to add insight into the effects surgeons observe during vitrectomy and how they change with a variety of console settings.
Methods: Laboratory-based investigation using in vitro testing was carried out at Newcastle University, United Kingdom. Testing was conducted using an Eva Nexus Vitrectomy system (D.
Water Res
August 2025
Key Laboratory of Environmental Aquatic Chemistry, State Key Laboratory of Regional Environment and Sustainability, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. Electronic address:
The ozone-ultraviolet (O-UV) process, which has emerged for advanced treatment of the secondary effluents (SEs) of wastewater treatment plants (WWTPs), requires optimization that balances the contributions of O (chemical oxidation) and hydroxyl radicals (HO, advanced oxidation) to minimize energy consumption. In this study, a novel bench-scale mini-fluidic O-UV system (MFOUS) was developed, allowing for accurate determination and convenient adjustment of the key operational parameters including O mass loading (ML) and UV fluence (F). The degradation of refractory organic compounds in the O-UV process, expressed by chemical oxygen demand (COD) reduction and biodegradability (i.
View Article and Find Full Text PDFDrug Metab Dispos
July 2025
CN Bio Innovations Ltd, Cambridge, United Kingdom.
Oral bioavailability is a crucial pharmacokinetic (PK) parameter optimized by drug developers working on new therapeutic compounds. The goal is to obtain adequate systemic exposure and to establish safe and effective therapeutic dosages. Critical to optimizing oral bioavailability is understanding a compound's susceptibility to first-pass metabolism, determined by the intricate relationship between gut absorption, metabolism, and hepatic metabolism.
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