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Based on the excitation of surface plasmon polaritons (SPPs), we analytically and numerically investigate the transmission response in metal-dielectric-metal (MDM) plasmonic waveguides with a side coupled nanocavity (SCNC). By filling the nanocavity with a Kerr nonlinear medium, the position of the resonant dip in the transmission spectrum can be tuned by the incident light intensity. The oscillation of a Fabry-Perot nanocavity formed by incorporating a finite length of the same Kerr nonlinear media into the MDM waveguide acts as a background for the transmission response of the system and induces a sharp and asymmetric response line shape. As a result, the wavelength shift required for the plasmonic device to be switched from the maximum to the minimum transmission can be reduced by half in a structure less than 400 nm long. Such an effect may be potentially applied to constructing SPP-based all-optical switching with low power threshold at nanoscale.
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http://dx.doi.org/10.1364/OE.18.000079 | DOI Listing |
J Neurophysiol
September 2025
Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, UT, USA.
Although glutamatergic and GABAergic synapses are important in seizure generation, the contribution of non-synaptic ionic and electrical mechanisms to synchronization of seizure-prone hippocampal neurons remains unclear. Here, we developed a physiologically relevant model to study these mechanisms by inducing prolonged seizure-like discharges (SLDs) in hippocampal slices from male rats through modest, sustained ionic manipulations. Specifically, we reduced extracellular calcium to 0.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
September 2025
M. Kumarasamy College of Engineering, Karur, 639113, Tamil Nadu, India.
Energy production from renewable resources remains a leading focus in sustainable power generation. Recently, bifacial photovoltaic (BPV) systems have gained global attention for their enhanced energy yield. In this study, seashell waste was repurposed as an alternative reflector material for BPV modules.
View Article and Find Full Text PDFJ Exp Med
November 2025
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Host-pathogen interactions involve two critical strategies: resistance, whereby hosts clear invading microbes, and tolerance, whereby hosts carry high pathogen burden asymptomatically. Here, we investigate mechanisms by which Salmonella-superspreader (SSP) hosts maintain an asymptomatic state during chronic infection. We found that regulatory T cells (Tregs) are essential for this disease-tolerant state, limiting intestinal immunopathology and enabling SSP hosts to thrive, while facilitating Salmonella transmission.
View Article and Find Full Text PDFMed Vet Entomol
September 2025
Laboratorio de Inmunología, Centro de Investigaciones Regionales "Dr. Hideyo Noguchi", Universidad Autónoma de Yucatán, Mérida, México.
The study of population dynamics in a vertical forest gradient provides basic information on the aspects of insect vector natural history that influence the rate of pathogen transmission. In Mexico, these studies are remarkably limited for sand flies recognised as Leishmania vectors. This study analyses the temporal dynamics of sand fly species (Diptera: Psychodidae) along vertical strata of a tropical dry forest in Yucatán, Mexico, an area previously identified as a transmission hotspot for Leishmania mexicana.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Department of Tuberculosis, Guiyang Public Health Clinical Center, Guiyang, Guizhou Province, China.
Rationale: We report an extremely rare case in which delayed diagnosis and treatment of Mycobacterium tuberculosis infection primarily involving the subcutaneous tissues of an extremity led to hematogenous dissemination of the infection and subsequent deterioration of the patient.
Patient Concerns: An 82-year-old man presented to our hospital with a painful mass on the right ankle for over a year, as well as persistent fever and shortness of breath for >14 days. He received piperacillin/tazobactam followed by meropenem, which failed to decrease his peak temperature.