Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Molecular characterization of tumour material will become increasingly important in selecting patients for clinical trials and offering appropriate treatment for patients in clinical practice. Recent advances in the field have indicated that the molecular characteristics of a tumour can be determined from circulating tumour cells and circulating tumour DNA; thus, a simple blood sample could provide these data in a simple, convenient and efficient manner. This article discusses progress towards guiding treatment decisions through measuring tumour-derived factors in the circulation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.drudis.2009.12.006 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Inhibition of Interleukin-1 Receptor-Associated Kinase-1 by Pacritinib Is a Therapeutic Strategy to Overcome Melanoma Resistance.
J Environ Pathol Toxicol Oncol
January 2025
Department of Pharmacy, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.
Despite advancements in systemic therapy, the mortality rate for patients with metastatic melanoma remains around 70%, underscoring the imperative for alternative treatment strategies. Through the establishment of a chemoresistant melanoma model and a subsequent drug investigation, we have identified pacritinib, a medication designed for treating myelofibrosis and severe thrombocytopenia, as a potential candidate to overcome resistance to melanoma therapy. Our research reveals that pacritinib, administered at clinically achievable concentrations, effectively targets dacarbazine-resistant melanoma cells by suppressing IRAK1 rather than JAK2.
View Article and Find Full Text PDFMobility impairment and fall concern predict wayfinding ability in persons with multiple sclerosis.
Mult Scler Relat Disord
September 2025
Department of Psychology, Wayne State University, Detroit, MI, 48202, USA; Institute of Gerontology, Wayne State University, Detroit, MI, 48202, USA; Translational Neuroscience Program, Wayne State University, Detroit, MI, 48201, USA. Electronic address:
The ability to navigate through one's environment is crucial for maintaining independence in daily life and depends on complex cognitive and motor functions that are vulnerable to decline in persons with Multiple Sclerosis (MS). While previous research suggests a role for mobility in the physical act of navigation, it remains unclear to what extent mobility impairment and perceptions of mobility constraints may modify wayfinding and the recall of environment details in support of successful navigation. Therefore, this study examined the relations among clinical mobility function, concern about falling, and recall of environment details in a clinical sample of MS.
View Article and Find Full Text PDFIsolated lumbar vertebral infection caused by Coxiella burnetii: A case report and literature review.
Diagn Microbiol Infect Dis
September 2025
Department of Infectious Diseases, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China. Electronic address:
This study describes the clinical characteristics and treatment of vertebral infection caused by Coxiella burnetii through a case report and literature review. We present a 60-year-old male with isolated lumbar vertebral infection. A comprehensive literature review identified 17 cases, with 82.
View Article and Find Full Text PDFEvaluating the effectiveness of ChemoNurse: A mobile chemotherapy drug guide for cancer nurses - A randomized controlled trial.
Eur J Oncol Nurs
August 2025
Koç University Hospital, Faculty of Medicine, Department of Medical Oncology, Istanbul, Türkiye. Electronic address:
Purpose: This study aimed to evaluate the effectiveness of a mobile chemotherapy drug guide application, ChemoNurse, developed for cancer nurses, in improving their knowledge and attitudes toward chemotherapy practices.
Methods: A randomized controlled trial with a repeated-measures design was conducted with 59 nurses (29 intervention, 30 control) who participated. Nurses in the intervention group used the ChemoNurse mobile application for six months, while the control group received no additional intervention.
Camera-assisted and navigated single-position prone transpsoas lateral lumbar interbody fusion: illustrative case.
J Neurosurg Case Lessons
September 2025
Department of Neurosurgery, University of Kentucky, Lexington, Kentucky.
Background: Single-position prone transpsoas lateral lumbar interbody fusion (PTP-LLIF) is an evolving minimally invasive surgery technique that merges the biomechanical and anatomical advantages of prone positioning with the LLIF approach. While PTP-LLIF enhances lumbar lordosis restoration and operative efficiency by eliminating patient repositioning, it presents unique ergonomic and visualization challenges for surgeons. This technical report describes a novel modification of the technique using the Teligen camera to improve intraoperative visualization and reduce surgeon fatigue.
View Article and Find Full Text PDF